ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Melanoma-derived growth regulatory protein

Intramolecular
Cysteine 36 and cysteine 41
Cysteine 59 and cysteine 130
A redox-regulated disulphide may form within Melanoma-derived growth regulatory protein between cysteines 36 and 41 (12 and 17 respectively in this structure).

Details

Redox score ?
88
PDB code
1i1j
Structure name
structure of melanoma inhibitory activity protein: a member of a new family of secreted proteins
Structure deposition date
2001-02-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16674
Residue number A
36
Residue number B
41
Peptide name
Melanoma-derived growth regulatory protein

Ligandability

Cysteine 36 of Melanoma-derived growth regulatory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 41 of Melanoma-derived growth regulatory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Melanoma-derived growth regulatory protein between cysteines 59 and 130 (35 and 106 respectively in this structure).

Details

Redox score ?
86
PDB code
5ixb
Structure name
structure of human melanoma inhibitory activity (mia) protein in complex with pyrimidin-2-amine
Structure deposition date
2016-03-23
Thiol separation (Å)
2
Half-sphere exposure sum ?
34
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16674
Residue number A
59
Residue number B
130
Peptide name
Melanoma-derived growth regulatory protein

Ligandability

Cysteine 59 of Melanoma-derived growth regulatory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 130 of Melanoma-derived growth regulatory protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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