ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dual specificity protein phosphatase 5

Intermolecular
Cysteine 251 and cysteine 251
Intramolecular
Cysteine 197 and cysteine 219
A redox-regulated disulphide may form between two units of Dual specificity protein phosphatase 5 at cysteines 251 and 251.

Details

Redox score ?
74
PDB code
2g6z
Structure name
crystal structure of human dusp5
Structure deposition date
2006-02-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
7
% buried
77
Peptide A name
Dual specificity protein phosphatase 5
Peptide B name
Dual specificity protein phosphatase 5
Peptide A accession
Q16690
Peptide B accession
Q16690
Peptide A residue number
251
Peptide B residue number
251

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dual specificity protein phosphatase 5 between cysteines 197 and 219.

Details

Redox score ?
85
PDB code
2g6z
Structure name
crystal structure of human dusp5
Structure deposition date
2006-02-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16690
Residue number A
197
Residue number B
219
Peptide name
Dual specificity protein phosphatase 5

Ligandability

Cysteine 197 of Dual specificity protein phosphatase 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 219 of Dual specificity protein phosphatase 5

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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