ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kynurenine--oxoglutarate transaminase 1

Intramolecular
Cysteine 203 and cysteine 210
Cysteine 316 and cysteine 400
A redox-regulated disulphide may form within Kynurenine--oxoglutarate transaminase 1 between cysteines 203 and 210.

Details

Redox score ?
63
PDB code
4wlj
Structure name
high resolution crystal structure of human kynurenine aminotransferase-i in complex with aminooxyacetate
Structure deposition date
2014-10-07
Thiol separation (Å)
5
Half-sphere exposure sum ?
84
Minimum pKa ?
8
% buried
98
Peptide accession
Q16773
Residue number A
203
Residue number B
210
Peptide name
Kynurenine--oxoglutarate transaminase 1

Ligandability

Cysteine 203 of Kynurenine--oxoglutarate transaminase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Kynurenine--oxoglutarate transaminase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Kynurenine--oxoglutarate transaminase 1 between cysteines 316 and 400. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
4wp0
Structure name
crystal structure of human kynurenine aminotransferase-i with a c- terminal v5-hexahistidine tag
Structure deposition date
2014-10-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
84
Peptide accession
Q16773
Residue number A
316
Residue number B
400
Peptide name
Kynurenine--oxoglutarate transaminase 1

Ligandability

Cysteine 316 of Kynurenine--oxoglutarate transaminase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 400 of Kynurenine--oxoglutarate transaminase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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