ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Hydroxyacylglutathione hydrolase, mitochondrial

Intramolecular
Cysteine 157 and cysteine 189
Cysteine 157 and cysteine 201
Cysteine 189 and cysteine 201
A redox-regulated disulphide may form within Hydroxyacylglutathione hydrolase, mitochondrial between cysteines 157 and 189 (109 and 141 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
1qh3
Structure name
human glyoxalase ii with cacodylate and acetate ions present in the active site
Structure deposition date
1999-05-10
Thiol separation (Å)
7
Half-sphere exposure sum ?
76
Minimum pKa ?
12
% buried
85
Peptide accession
Q16775
Residue number A
157
Residue number B
189
Peptide name
Hydroxyacylglutathione hydrolase, mitochondrial

Ligandability

Cysteine 157 of Hydroxyacylglutathione hydrolase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 189 of Hydroxyacylglutathione hydrolase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hydroxyacylglutathione hydrolase, mitochondrial between cysteines 157 and 201 (109 and 153 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
1qh5
Structure name
human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
Structure deposition date
1999-05-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
11
% buried
66
Peptide accession
Q16775
Residue number A
157
Residue number B
201
Peptide name
Hydroxyacylglutathione hydrolase, mitochondrial

Ligandability

Cysteine 157 of Hydroxyacylglutathione hydrolase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Hydroxyacylglutathione hydrolase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hydroxyacylglutathione hydrolase, mitochondrial between cysteines 189 and 201 (141 and 153 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
30
PDB code
1qh5
Structure name
human glyoxalase ii with s-(n-hydroxy-n-bromophenylcarbamoyl) glutathione
Structure deposition date
1999-05-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
80
Minimum pKa ?
11
% buried
76
Peptide accession
Q16775
Residue number A
189
Residue number B
201
Peptide name
Hydroxyacylglutathione hydrolase, mitochondrial

Ligandability

Cysteine 189 of Hydroxyacylglutathione hydrolase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 201 of Hydroxyacylglutathione hydrolase, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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