a tool for identifying drug-targetable redox-active disulphides

Carbonic anhydrase 9

Intramolecular

Cysteine 156 and cysteine 336

A redox-regulated disulphide may form within Carbonic anhydrase 9 between cysteines 156 and 336 (23 and 203 respectively in this structure).

Details

Redox score ?

83

PDB code

Structure name

three dimensional structure of human carbonic anhydrase ix in complex with benzenesulfonamide

Structure deposition date

2019-02-08

Thiol separation (Å)

2

Half-sphere exposure sum ?

66

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

156

Residue number B

336

Peptide name

Carbonic anhydrase 9

Ligandability

Cysteine 156 of Carbonic anhydrase 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 336 of Carbonic anhydrase 9

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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