ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Meprin A subunit beta

Intermolecular
Cysteine 305 and cysteine 305
Intramolecular
Cysteine 340 and cysteine 427
Cysteine 103 and cysteine 255
Cysteine 124 and cysteine 144
Cysteine 265 and cysteine 273
A redox-regulated disulphide may form between two units of Meprin A subunit beta at cysteines 305 and 305.

Details

Redox score ?
86
PDB code
7aq1
Structure name
crystal structure of human mature meprin beta in complex with the specific inhibitor mwt-s-270
Structure deposition date
2020-10-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
48
Minimum pKa ?
nan
% buried
nan
Peptide A name
Meprin A subunit beta
Peptide B name
Meprin A subunit beta
Peptide A accession
Q16820
Peptide B accession
Q16820
Peptide A residue number
305
Peptide B residue number
305

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Meprin A subunit beta between cysteines 340 and 427.

Details

Redox score ?
83
PDB code
7aq1
Structure name
crystal structure of human mature meprin beta in complex with the specific inhibitor mwt-s-270
Structure deposition date
2020-10-20
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16820
Residue number A
340
Residue number B
427
Peptide name
Meprin A subunit beta

Ligandability

Cysteine 340 of Meprin A subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 427 of Meprin A subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Meprin A subunit beta between cysteines 103 and 255.

Details

Redox score ?
82
PDB code
7auw
Structure name
inhibitory complex of human meprin beta with mouse fetuin-b
Structure deposition date
2020-11-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16820
Residue number A
103
Residue number B
255
Peptide name
Meprin A subunit beta

Ligandability

Cysteine 103 of Meprin A subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 255 of Meprin A subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Meprin A subunit beta between cysteines 124 and 144.

Details

Redox score ?
81
PDB code
7auw
Structure name
inhibitory complex of human meprin beta with mouse fetuin-b
Structure deposition date
2020-11-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16820
Residue number A
124
Residue number B
144
Peptide name
Meprin A subunit beta

Ligandability

Cysteine 124 of Meprin A subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 144 of Meprin A subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Meprin A subunit beta between cysteines 265 and 273.

Details

Redox score ?
72
PDB code
4gwm
Structure name
crystal structure of human promeprin beta
Structure deposition date
2012-09-03
Thiol separation (Å)
3
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
98
Peptide accession
Q16820
Residue number A
265
Residue number B
273
Peptide name
Meprin A subunit beta

Ligandability

Cysteine 265 of Meprin A subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 273 of Meprin A subunit beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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