ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Receptor-type tyrosine-protein phosphatase O

Intramolecular
Cysteine 1039 and cysteine 1047
Cysteine 1047 and cysteine 1136
A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase O between cysteines 1039 and 1047.

Details

Redox score ?
61
PDB code
2gjt
Structure name
crystal structure of the human receptor phosphatase ptpro
Structure deposition date
2006-03-31
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
11
% buried
78
Peptide accession
Q16827
Residue number A
1039
Residue number B
1047
Peptide name
Receptor-type tyrosine-protein phosphatase O

Ligandability

Cysteine 1039 of Receptor-type tyrosine-protein phosphatase O

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1047 of Receptor-type tyrosine-protein phosphatase O

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Receptor-type tyrosine-protein phosphatase O between cysteines 1047 and 1136 (136 and 225 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
2g59
Structure name
crystal structure of the catalytic domain of protein tyrosine phosphatase from homo sapiens
Structure deposition date
2006-02-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
9
% buried
100
Peptide accession
Q16827
Residue number A
1047
Residue number B
1136
Peptide name
Receptor-type tyrosine-protein phosphatase O

Ligandability

Cysteine 1047 of Receptor-type tyrosine-protein phosphatase O

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1136 of Receptor-type tyrosine-protein phosphatase O

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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