ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Dual specificity protein phosphatase 6

Intramolecular
Cysteine 90 and cysteine 127
Cysteine 39 and cysteine 147
A redox-regulated disulphide may form within Dual specificity protein phosphatase 6 between cysteines 90 and 127. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
57
PDB code
1hzm
Structure name
structure of erk2 binding domain of mapk phosphatase mkp-3: structural insights into mkp-3 activation by erk2
Structure deposition date
2001-01-25
Thiol separation (Å)
8
Half-sphere exposure sum ?
55
Minimum pKa ?
9
% buried
25
Peptide accession
Q16828
Residue number A
90
Residue number B
127
Peptide name
Dual specificity protein phosphatase 6

Ligandability

Cysteine 90 of Dual specificity protein phosphatase 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of Dual specificity protein phosphatase 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Dual specificity protein phosphatase 6 between cysteines 39 and 147. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
1hzm
Structure name
structure of erk2 binding domain of mapk phosphatase mkp-3: structural insights into mkp-3 activation by erk2
Structure deposition date
2001-01-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
88
Minimum pKa ?
11
% buried
76
Peptide accession
Q16828
Residue number A
39
Residue number B
147
Peptide name
Dual specificity protein phosphatase 6

Ligandability

Cysteine 39 of Dual specificity protein phosphatase 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 147 of Dual specificity protein phosphatase 6

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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