Uridine phosphorylase 1

Intramolecular

A redox-regulated disulphide may form within Uridine phosphorylase 1 between cysteines 258 and 261. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

3nbq

Structure name

human uridine phosphorylase 1 (hupp1) with 5-fluorouracil

Structure deposition date

2010-06-03

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q16831

Residue number A

258

Residue number B

261

Peptide name

Uridine phosphorylase 1

Ligandability

Cysteine 258 of Uridine phosphorylase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of Uridine phosphorylase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Uridine phosphorylase 1 between cysteines 57 and 71. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

PDB code

3euf

Structure name

crystal structure of bau-bound human uridine phosphorylase 1

Structure deposition date

2008-10-10

Thiol separation (Å)

Half-sphere exposure sum ?

Minimum pK_a ?

% buried

Peptide accession

Q16831

Residue number A

Residue number B

Peptide name

Uridine phosphorylase 1

Ligandability

Cysteine 57 of Uridine phosphorylase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 71 of Uridine phosphorylase 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Uridine phosphorylase 1 between cysteines 209 and 269. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?