Discoidin domain-containing receptor 2
Intramolecular
Cysteine 30 and cysteine 185
Cysteine 73 and cysteine 177
Cysteine 644 and cysteine 651
Cysteine 580 and cysteine 651
Cysteine 580 and cysteine 644
Cysteine 716 and cysteine 784
7azb A 31 A 186
A redox-regulated disulphide may form within Discoidin domain-containing receptor 2 between cysteines 30 and 185 (31 and 186 respectively in this structure).
Details
Redox score ?
83
PDB code
7azb
Structure name
structure of ddr2 ds domain in complex with vhh
Structure deposition date
2020-11-16
Thiol separation (Å)
3
Half-sphere exposure sum ?
45
Minimum pKa ?
8
% buried
0
Peptide accession
Q16832
Residue number A
30
Residue number B
185
Peptide name
Discoidin domain-containing receptor 2
Ligandability
Cysteine 30 of Discoidin domain-containing receptor 2
Cysteine 185 of Discoidin domain-containing receptor 2
2wuh A 73 A 177
A redox-regulated disulphide may form within Discoidin domain-containing receptor 2 between cysteines 73 and 177.
Details
Redox score ?
74
PDB code
2wuh
Structure name
crystal structure of the ddr2 discoidin domain bound to a triple-helical collagen peptide
Structure deposition date
2009-10-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
105
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16832
Residue number A
73
Residue number B
177
Peptide name
Discoidin domain-containing receptor 2
Ligandability
Cysteine 73 of Discoidin domain-containing receptor 2
Cysteine 177 of Discoidin domain-containing receptor 2
6fer C 691 C 698
A redox-regulated disulphide may form within Discoidin domain-containing receptor 2 between cysteines 644 and 651 (691 and 698 respectively in this structure).
Details
Redox score ?
67
PDB code
6fer
Structure name
crystal structure of human ddr2 kinase in complex with 2-[4,5- difluoro-2-oxo-1'-(1h-pyrazolo[3,4-b]pyridine-5-carbonyl) spiro[indole-3,4'-piperidine]-1-yl]-n-(2,2,2-trifluoroethyl)acetamide
Structure deposition date
2018-01-03
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
10
% buried
54
Peptide accession
Q16832
Residue number A
644
Residue number B
651
Peptide name
Discoidin domain-containing receptor 2
Ligandability
Cysteine 644 of Discoidin domain-containing receptor 2
Cysteine 651 of Discoidin domain-containing receptor 2
6fer E 627 E 698
A redox-regulated disulphide may form within Discoidin domain-containing receptor 2 between cysteines 580 and 651 (627 and 698 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
6fer
Structure name
crystal structure of human ddr2 kinase in complex with 2-[4,5- difluoro-2-oxo-1'-(1h-pyrazolo[3,4-b]pyridine-5-carbonyl) spiro[indole-3,4'-piperidine]-1-yl]-n-(2,2,2-trifluoroethyl)acetamide
Structure deposition date
2018-01-03
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
10
% buried
66
Peptide accession
Q16832
Residue number A
580
Residue number B
651
Peptide name
Discoidin domain-containing receptor 2
Ligandability
Cysteine 580 of Discoidin domain-containing receptor 2
Cysteine 651 of Discoidin domain-containing receptor 2
6fer E 627 E 691
A redox-regulated disulphide may form within Discoidin domain-containing receptor 2 between cysteines 580 and 644 (627 and 691 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
38
PDB code
6fer
Structure name
crystal structure of human ddr2 kinase in complex with 2-[4,5- difluoro-2-oxo-1'-(1h-pyrazolo[3,4-b]pyridine-5-carbonyl) spiro[indole-3,4'-piperidine]-1-yl]-n-(2,2,2-trifluoroethyl)acetamide
Structure deposition date
2018-01-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
11
% buried
51
Peptide accession
Q16832
Residue number A
580
Residue number B
644
Peptide name
Discoidin domain-containing receptor 2
Ligandability
Cysteine 580 of Discoidin domain-containing receptor 2
Cysteine 644 of Discoidin domain-containing receptor 2
6fer E 763 E 831
A redox-regulated disulphide may form within Discoidin domain-containing receptor 2 between cysteines 716 and 784 (763 and 831 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
32
PDB code
6fer
Structure name
crystal structure of human ddr2 kinase in complex with 2-[4,5- difluoro-2-oxo-1'-(1h-pyrazolo[3,4-b]pyridine-5-carbonyl) spiro[indole-3,4'-piperidine]-1-yl]-n-(2,2,2-trifluoroethyl)acetamide
Structure deposition date
2018-01-03
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
100
Peptide accession
Q16832
Residue number A
716
Residue number B
784
Peptide name
Discoidin domain-containing receptor 2
Ligandability
Cysteine 716 of Discoidin domain-containing receptor 2
Cysteine 784 of Discoidin domain-containing receptor 2
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