ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

Membrane primary amine oxidase

Intermolecular
Cysteine 748 and cysteine 748
Cysteine 41 and cysteine 41
Cysteine 41 and cysteine 748
Intramolecular
Cysteine 198 and cysteine 199
Cysteine 734 and cysteine 741
Cysteine 404 and cysteine 430
A redox-regulated disulphide may form between two units of Membrane primary amine oxidase at cysteines 748 and 748.

Details

Redox score ?
83
PDB code
4bty
Structure name
crystal structure of human vascular adhesion protein-1 in complex with pyridazinone inhibitors
Structure deposition date
2013-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide A name
Membrane primary amine oxidase
Peptide B name
Membrane primary amine oxidase
Peptide A accession
Q16853
Peptide B accession
Q16853
Peptide A residue number
748
Peptide B residue number
748

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Membrane primary amine oxidase at cysteines 41 and 41. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3ala
Structure name
crystal structure of vascular adhesion protein-1 in space group c2
Structure deposition date
2010-07-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide A name
Membrane primary amine oxidase
Peptide B name
Membrane primary amine oxidase
Peptide A accession
Q16853
Peptide B accession
Q16853
Peptide A residue number
41
Peptide B residue number
41

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between two units of Membrane primary amine oxidase at cysteines 41 and 748. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
3ala
Structure name
crystal structure of vascular adhesion protein-1 in space group c2
Structure deposition date
2010-07-29
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide A name
Membrane primary amine oxidase
Peptide B name
Membrane primary amine oxidase
Peptide A accession
Q16853
Peptide B accession
Q16853
Peptide A residue number
41
Peptide B residue number
748

Ligandability

Cysteine 41 of Membrane primary amine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 748 of Membrane primary amine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Membrane primary amine oxidase between cysteines 198 and 199.

Details

Redox score ?
84
PDB code
4bty
Structure name
crystal structure of human vascular adhesion protein-1 in complex with pyridazinone inhibitors
Structure deposition date
2013-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16853
Residue number A
198
Residue number B
199
Peptide name
Membrane primary amine oxidase

Ligandability

Cysteine 198 of Membrane primary amine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of Membrane primary amine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Membrane primary amine oxidase between cysteines 734 and 741.

Details

Redox score ?
84
PDB code
4btx
Structure name
crystal structure of human vascular adhesion protein-1 in complex with pyridazinone inhibitors
Structure deposition date
2013-06-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16853
Residue number A
734
Residue number B
741
Peptide name
Membrane primary amine oxidase

Ligandability

Cysteine 734 of Membrane primary amine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 741 of Membrane primary amine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Membrane primary amine oxidase between cysteines 404 and 430.

Details

Redox score ?
79
PDB code
2c11
Structure name
crystal structure of the 2-hydrazinopyridine of semicarbazide- sensitive amine oxidase
Structure deposition date
2005-09-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
85
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q16853
Residue number A
404
Residue number B
430
Peptide name
Membrane primary amine oxidase

Ligandability

Cysteine 404 of Membrane primary amine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 430 of Membrane primary amine oxidase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: