ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Cysteine dioxygenase type 1

Intramolecular
Cysteine 93 and cysteine 164
Cysteine 93 and cysteine 130
Cysteine 164 and cysteine 502
Cysteine 93 and cysteine 301
Cysteine 164 and cysteine 301
A redox-regulated disulphide may form within Cysteine dioxygenase type 1 between cysteines 93 and 164. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
6n42
Structure name
crystal structure of cysteine-bound ferrous form of the crosslinked human cysteine dioxygenase in the anaerobic condition
Structure deposition date
2018-11-16
Thiol separation (Å)
10
Half-sphere exposure sum ?
62
Minimum pKa ?
10
% buried
nan
Peptide accession
Q16878
Residue number A
93
Residue number B
164
Peptide name
Cysteine dioxygenase type 1

Ligandability

Cysteine 93 of Cysteine dioxygenase type 1

Cysteine 164 of Cysteine dioxygenase type 1

A redox-regulated disulphide may form within Cysteine dioxygenase type 1 between cysteines 93 and 130. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6e87
Structure name
crystal structure of ferrous form of the crosslinked human cysteine dioxygenase in the anaerobic condition
Structure deposition date
2018-07-27
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
nan
Peptide accession
Q16878
Residue number A
93
Residue number B
130
Peptide name
Cysteine dioxygenase type 1

Ligandability

Cysteine 93 of Cysteine dioxygenase type 1

Cysteine 130 of Cysteine dioxygenase type 1

A redox-regulated disulphide may form within Cysteine dioxygenase type 1 between cysteines 164 and 502.

Details

Redox score ?
nan
PDB code
4xf0
Structure name
cysteine dioxygenase variant - c93a at ph 8
Structure deposition date
2014-12-25
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
nan
Peptide accession
P21816
Residue number A
164
Residue number B
502
Peptide name
Cysteine dioxygenase type 1

Ligandability

Cysteine 164 of Cysteine dioxygenase type 1

Cysteine 502 of Cysteine dioxygenase type 1

Cysteine 502 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Cysteine dioxygenase type 1 between cysteines 93 and 301.

Details

Redox score ?
nan
PDB code
6n43
Structure name
crystal structure of cysteine, nitric oxide-bound ferrous form of the crosslinked human cysteine dioxygenase in the anaerobic condition
Structure deposition date
2018-11-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
nan
Minimum pKa ?
6
% buried
nan
Peptide accession
Q16878
Residue number A
93
Residue number B
301
Peptide name
Cysteine dioxygenase type 1

Ligandability

Cysteine 93 of Cysteine dioxygenase type 1

Cysteine 301 of Cysteine dioxygenase type 1

Cysteine 301 in protein B could not be asigned to a Uniprot residue.
A redox-regulated disulphide may form within Cysteine dioxygenase type 1 between cysteines 164 and 301.

Details

Redox score ?
nan
PDB code
6n43
Structure name
crystal structure of cysteine, nitric oxide-bound ferrous form of the crosslinked human cysteine dioxygenase in the anaerobic condition
Structure deposition date
2018-11-16
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
nan
Peptide accession
Q16878
Residue number A
164
Residue number B
301
Peptide name
Cysteine dioxygenase type 1

Ligandability

Cysteine 164 of Cysteine dioxygenase type 1

Cysteine 301 of Cysteine dioxygenase type 1

Cysteine 301 in protein B could not be asigned to a Uniprot residue.
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