ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Flap endonuclease GEN homolog 1

Intramolecular
Cysteine 321 and cysteine 322
Cysteine 322 and cysteine 323
Cysteine 139 and cysteine 151
Cysteine 321 and cysteine 323
A redox-regulated disulphide may form within Flap endonuclease GEN homolog 1 between cysteines 321 and 322. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
60
PDB code
5t9j
Structure name
crystal structure of human gen1 in complex with holliday junction dna in the upper interface
Structure deposition date
2016-09-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
48
Minimum pKa ?
10
% buried
20
Peptide accession
Q17RS7
Residue number A
321
Residue number B
322
Peptide name
Flap endonuclease GEN homolog 1

Ligandability

Cysteine 321 of Flap endonuclease GEN homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 322 of Flap endonuclease GEN homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Flap endonuclease GEN homolog 1 between cysteines 322 and 323. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
5t9j
Structure name
crystal structure of human gen1 in complex with holliday junction dna in the upper interface
Structure deposition date
2016-09-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
38
Minimum pKa ?
9
% buried
6
Peptide accession
Q17RS7
Residue number A
322
Residue number B
323
Peptide name
Flap endonuclease GEN homolog 1

Ligandability

Cysteine 322 of Flap endonuclease GEN homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Flap endonuclease GEN homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Flap endonuclease GEN homolog 1 between cysteines 139 and 151. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
48
PDB code
5t9j
Structure name
crystal structure of human gen1 in complex with holliday junction dna in the upper interface
Structure deposition date
2016-09-09
Thiol separation (Å)
5
Half-sphere exposure sum ?
103
Minimum pKa ?
13
% buried
100
Peptide accession
Q17RS7
Residue number A
139
Residue number B
151
Peptide name
Flap endonuclease GEN homolog 1

Ligandability

Cysteine 139 of Flap endonuclease GEN homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 151 of Flap endonuclease GEN homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Flap endonuclease GEN homolog 1 between cysteines 321 and 323. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
5t9j
Structure name
crystal structure of human gen1 in complex with holliday junction dna in the upper interface
Structure deposition date
2016-09-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
42
Minimum pKa ?
9
% buried
18
Peptide accession
Q17RS7
Residue number A
321
Residue number B
323
Peptide name
Flap endonuclease GEN homolog 1

Ligandability

Cysteine 321 of Flap endonuclease GEN homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 323 of Flap endonuclease GEN homolog 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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