ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytoplasmic polyadenylation element-binding protein 4

Intramolecular
Cysteine 535 and cysteine 545
A redox-regulated disulphide may form within Cytoplasmic polyadenylation element-binding protein 4 between cysteines 535 and 545 (128 and 138 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
58
PDB code
2mkj
Structure name
solution structure of tandem rrm domains of cytoplasmic polyadenylation element binding protein 4 (cpeb4) in free state
Structure deposition date
2014-02-07
Thiol separation (Å)
7
Half-sphere exposure sum ?
49
Minimum pKa ?
9
% buried
17
Peptide accession
Q17RY0
Residue number A
535
Residue number B
545
Peptide name
Cytoplasmic polyadenylation element-binding protein 4

Ligandability

Cysteine 535 of Cytoplasmic polyadenylation element-binding protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 545 of Cytoplasmic polyadenylation element-binding protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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