ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Protein Dok-7

Intermolecular
Cysteine 45 and cysteine 45
Intramolecular
Cysteine 63 and cysteine 82
Cysteine 63 and cysteine 134
Cysteine 35 and cysteine 82
Cysteine 82 and cysteine 134
A redox-regulated disulphide may form between two units of Protein Dok-7 at cysteines 45 and 45. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3ml4
Structure name
crystal structure of a complex between dok7 ph-ptb and the musk juxtamembrane region
Structure deposition date
2010-04-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
38
Minimum pKa ?
9
% buried
0
Peptide A name
Protein Dok-7
Peptide B name
Protein Dok-7
Peptide A accession
Q18PE0
Peptide B accession
Q18PE0
Peptide A residue number
45
Peptide B residue number
45

Ligandability

A redox-regulated disulphide may form within Protein Dok-7 between cysteines 63 and 82. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
47
PDB code
3ml4
Structure name
crystal structure of a complex between dok7 ph-ptb and the musk juxtamembrane region
Structure deposition date
2010-04-16
Thiol separation (Å)
6
Half-sphere exposure sum ?
77
Minimum pKa ?
12
% buried
63
Peptide accession
Q18PE0
Residue number A
63
Residue number B
82
Peptide name
Protein Dok-7

Ligandability

Cysteine 63 of Protein Dok-7

Cysteine 82 of Protein Dok-7

A redox-regulated disulphide may form within Protein Dok-7 between cysteines 63 and 134. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
3ml4
Structure name
crystal structure of a complex between dok7 ph-ptb and the musk juxtamembrane region
Structure deposition date
2010-04-16
Thiol separation (Å)
7
Half-sphere exposure sum ?
84
Minimum pKa ?
12
% buried
80
Peptide accession
Q18PE0
Residue number A
63
Residue number B
134
Peptide name
Protein Dok-7

Ligandability

Cysteine 63 of Protein Dok-7

Cysteine 134 of Protein Dok-7

A redox-regulated disulphide may form within Protein Dok-7 between cysteines 35 and 82. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
3ml4
Structure name
crystal structure of a complex between dok7 ph-ptb and the musk juxtamembrane region
Structure deposition date
2010-04-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
11
% buried
56
Peptide accession
Q18PE0
Residue number A
35
Residue number B
82
Peptide name
Protein Dok-7

Ligandability

Cysteine 35 of Protein Dok-7

Cysteine 82 of Protein Dok-7

A redox-regulated disulphide may form within Protein Dok-7 between cysteines 82 and 134. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
3ml4
Structure name
crystal structure of a complex between dok7 ph-ptb and the musk juxtamembrane region
Structure deposition date
2010-04-16
Thiol separation (Å)
9
Half-sphere exposure sum ?
75
Minimum pKa ?
12
% buried
81
Peptide accession
Q18PE0
Residue number A
82
Residue number B
134
Peptide name
Protein Dok-7

Ligandability

Cysteine 82 of Protein Dok-7

Cysteine 134 of Protein Dok-7

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