a tool for identifying drug-targetable redox-active disulphides

Dual oxidase maturation factor 1

Intramolecular

Cysteine 167 and cysteine 234

A redox-regulated disulphide may form within Dual oxidase maturation factor 1 between cysteines 167 and 234.

Details

Redox score ?

83

PDB code

Structure name

cryo-em structure of human duox1-duoxa1 in low-calcium state

Structure deposition date

2020-09-19

Thiol separation (Å)

2

Half-sphere exposure sum ?

65

Minimum pK_a ?

nan

% buried

nan

Peptide accession

Residue number A

167

Residue number B

234

Peptide name

Dual oxidase maturation factor 1

Ligandability

Cysteine 167 of Dual oxidase maturation factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 234 of Dual oxidase maturation factor 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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