a tool for identifying drug-targetable redox-active disulphides

Kazal domain-containing peptide

Intermolecular

Cysteine 33 and cysteine 784 of Plasminogen L

A redox-regulated disulphide may form between cysteine 33 of Kazal domain-containing peptide and cysteine 784 of Plasminogen (11 and 765 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

40

PDB code

Structure name

crystal structure of human microplasmin in complex with kazal-type inhibitor aati

Structure deposition date

2021-02-16

Thiol separation (Å)

9

Half-sphere exposure sum ?

76

Minimum pK_a ?

nan

% buried

nan

Peptide A name

Kazal domain-containing peptide

Peptide B name

Plasminogen

Peptide A accession

Peptide B accession

Peptide A residue number

33

Peptide B residue number

784

Ligandability

Cysteine 33 of Kazal domain-containing peptide

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 784 of Plasminogen

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: