a tool for identifying drug-targetable redox-active disulphides

Protein inscuteable homolog

Intramolecular

Cysteine 90 and cysteine 92

A redox-regulated disulphide may form within Protein inscuteable homolog between cysteines 90 and 92 (43 and 45 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

58

PDB code

Structure name

crystal structure of the complex between the conserved cell polarity proteins inscuteable and lgn

Structure deposition date

2011-06-12

Thiol separation (Å)

6

Half-sphere exposure sum ?

65

Minimum pK_a ?

9

% buried

69

Peptide accession

Residue number A

90

Residue number B

92

Peptide name

Protein inscuteable homolog

Ligandability

Cysteine 90 of Protein inscuteable homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 92 of Protein inscuteable homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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