ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytotoxic T-lymphocyte protein 4

Intramolecular
Cysteine 83 and cysteine 101
Cysteine 56 and cysteine 127
Cysteine 83 and cysteine 127
A redox-regulated disulphide may form within Cytotoxic T-lymphocyte protein 4 between cysteines 83 and 101.

Details

Redox score ?
84
PDB code
4kkn
Structure name
crystal structure of bovine ctla-4, psi-nysgrc-012704
Structure deposition date
2013-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q28090
Residue number A
83
Residue number B
101
Peptide name
Cytotoxic T-lymphocyte protein 4

Ligandability

Cysteine 83 of Cytotoxic T-lymphocyte protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 101 of Cytotoxic T-lymphocyte protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytotoxic T-lymphocyte protein 4 between cysteines 56 and 127.

Details

Redox score ?
81
PDB code
4kkn
Structure name
crystal structure of bovine ctla-4, psi-nysgrc-012704
Structure deposition date
2013-05-06
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q28090
Residue number A
56
Residue number B
127
Peptide name
Cytotoxic T-lymphocyte protein 4

Ligandability

Cysteine 56 of Cytotoxic T-lymphocyte protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of Cytotoxic T-lymphocyte protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytotoxic T-lymphocyte protein 4 between cysteines 83 and 127. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4kkn
Structure name
crystal structure of bovine ctla-4, psi-nysgrc-012704
Structure deposition date
2013-05-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q28090
Residue number A
83
Residue number B
127
Peptide name
Cytotoxic T-lymphocyte protein 4

Ligandability

Cysteine 83 of Cytotoxic T-lymphocyte protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 127 of Cytotoxic T-lymphocyte protein 4

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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