ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HLA class II DR-beta (HLA-DR B)

Intramolecular
Cysteine 146 and cysteine 202
Cysteine 44 and cysteine 108
A redox-regulated disulphide may form within HLA class II DR-beta (HLA-DR B) between cysteines 146 and 202 (117 and 173 respectively in this structure).

Details

Redox score ?
79
PDB code
6biz
Structure name
hla-drb1 in complex with citrullinated histone 2b peptide
Structure deposition date
2017-11-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q29890
Residue number A
146
Residue number B
202
Peptide name
HLA class II DR-beta (HLA-DR B)

Ligandability

Cysteine 146 of HLA class II DR-beta (HLA-DR B)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of HLA class II DR-beta (HLA-DR B)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA class II DR-beta (HLA-DR B) between cysteines 44 and 108 (15 and 79 respectively in this structure).

Details

Redox score ?
79
PDB code
6bix
Structure name
hla-drb1 in complex with citrullinated ll37 peptide
Structure deposition date
2017-11-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q29890
Residue number A
44
Residue number B
108
Peptide name
HLA class II DR-beta (HLA-DR B)

Ligandability

Cysteine 44 of HLA class II DR-beta (HLA-DR B)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of HLA class II DR-beta (HLA-DR B)

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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