ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class I polypeptide-related sequence B

Intramolecular
Cysteine 119 and cysteine 187
Cysteine 225 and cysteine 282
A redox-regulated disulphide may form within MHC class I polypeptide-related sequence B between cysteines 119 and 187 (96 and 164 respectively in this structure).

Details

Redox score ?
81
PDB code
1je6
Structure name
structure of the mhc class i homolog micb
Structure deposition date
2001-06-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
74
Minimum pKa ?
nan
% buried
nan
Peptide accession
P79525
Residue number A
119
Residue number B
187
Peptide name
MHC class I polypeptide-related sequence B

Ligandability

Cysteine 119 of MHC class I polypeptide-related sequence B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of MHC class I polypeptide-related sequence B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I polypeptide-related sequence B between cysteines 225 and 282 (202 and 259 respectively in this structure).

Details

Redox score ?
80
PDB code
1je6
Structure name
structure of the mhc class i homolog micb
Structure deposition date
2001-06-15
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
P79525
Residue number A
225
Residue number B
282
Peptide name
MHC class I polypeptide-related sequence B

Ligandability

Cysteine 225 of MHC class I polypeptide-related sequence B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of MHC class I polypeptide-related sequence B

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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