ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

MHC class I polypeptide-related sequence A

Intramolecular
Cysteine 59 and cysteine 64
Cysteine 119 and cysteine 187
Cysteine 225 and cysteine 282
A redox-regulated disulphide may form within MHC class I polypeptide-related sequence A between cysteines 59 and 64 (36 and 41 respectively in this structure).

Details

Redox score ?
87
PDB code
1hyr
Structure name
crystal structure of human mica in complex with natural killer cell receptor nkg2d
Structure deposition date
2001-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TQ92
Residue number A
59
Residue number B
64
Peptide name
MHC class I polypeptide-related sequence A

Ligandability

Cysteine 59 of MHC class I polypeptide-related sequence A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 64 of MHC class I polypeptide-related sequence A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I polypeptide-related sequence A between cysteines 119 and 187 (96 and 164 respectively in this structure).

Details

Redox score ?
81
PDB code
1hyr
Structure name
crystal structure of human mica in complex with natural killer cell receptor nkg2d
Structure deposition date
2001-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TQ92
Residue number A
119
Residue number B
187
Peptide name
MHC class I polypeptide-related sequence A

Ligandability

Cysteine 119 of MHC class I polypeptide-related sequence A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of MHC class I polypeptide-related sequence A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I polypeptide-related sequence A between cysteines 225 and 282 (202 and 259 respectively in this structure).

Details

Redox score ?
79
PDB code
1hyr
Structure name
crystal structure of human mica in complex with natural killer cell receptor nkg2d
Structure deposition date
2001-01-21
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q9TQ92
Residue number A
225
Residue number B
282
Peptide name
MHC class I polypeptide-related sequence A

Ligandability

Cysteine 225 of MHC class I polypeptide-related sequence A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of MHC class I polypeptide-related sequence A

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: