ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Coiled-coil-helix-coiled-coil-helix domain containing 1

Intramolecular
Cysteine 55 and cysteine 66
Cysteine 45 and cysteine 76
A redox-regulated disulphide may form within Coiled-coil-helix-coiled-coil-helix domain containing 1 between cysteines 55 and 66.

Details

Redox score ?
86
PDB code
6nf8
Structure name
structure of human mitochondrial translation initiation factor 3 bound to the small ribosomal subunit -class i
Structure deposition date
2018-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
44
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2HJE8
Residue number A
55
Residue number B
66
Peptide name
Coiled-coil-helix-coiled-coil-helix domain containing 1

Ligandability

Cysteine 55 of Coiled-coil-helix-coiled-coil-helix domain containing 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 66 of Coiled-coil-helix-coiled-coil-helix domain containing 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Coiled-coil-helix-coiled-coil-helix domain containing 1 between cysteines 45 and 76.

Details

Redox score ?
82
PDB code
3jd5
Structure name
cryo-em structure of the small subunit of the mammalian mitochondrial ribosome
Structure deposition date
2016-04-08
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2HJE8
Residue number A
45
Residue number B
76
Peptide name
Coiled-coil-helix-coiled-coil-helix domain containing 1

Ligandability

Cysteine 45 of Coiled-coil-helix-coiled-coil-helix domain containing 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 76 of Coiled-coil-helix-coiled-coil-helix domain containing 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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