ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Zinc finger protein 423

Intramolecular
Cysteine 961 and cysteine 964
Cysteine 932 and cysteine 935
A redox-regulated disulphide may form within Zinc finger protein 423 between cysteines 961 and 964 (35 and 38 respectively in this structure).

Details

Redox score ?
89
PDB code
2mdg
Structure name
solution nmr structure of zinc finger protein 423 from homo sapiens, northeast structural genomics consortium (nesg) target hr7298f
Structure deposition date
2013-09-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
35
Minimum pKa ?
6
% buried
0
Peptide accession
Q2M1K9
Residue number A
961
Residue number B
964
Peptide name
Zinc finger protein 423

Ligandability

Cysteine 961 of Zinc finger protein 423

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 964 of Zinc finger protein 423

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Zinc finger protein 423 between cysteines 932 and 935 (6 and 9 respectively in this structure).

Details

Redox score ?
86
PDB code
2mdg
Structure name
solution nmr structure of zinc finger protein 423 from homo sapiens, northeast structural genomics consortium (nesg) target hr7298f
Structure deposition date
2013-09-10
Thiol separation (Å)
4
Half-sphere exposure sum ?
36
Minimum pKa ?
8
% buried
0
Peptide accession
Q2M1K9
Residue number A
932
Residue number B
935
Peptide name
Zinc finger protein 423

Ligandability

Cysteine 932 of Zinc finger protein 423

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 935 of Zinc finger protein 423

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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