ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Kinesin-like protein KIF7

Intramolecular
Cysteine 74 and cysteine 325
A redox-regulated disulphide may form within Kinesin-like protein KIF7 between cysteines 74 and 325 (71 and 322 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
4a14
Structure name
human kif7, a kinesin involved in hedgehog signalling
Structure deposition date
2011-09-14
Thiol separation (Å)
9
Half-sphere exposure sum ?
86
Minimum pKa ?
11
% buried
96
Peptide accession
Q2M1P5
Residue number A
74
Residue number B
325
Peptide name
Kinesin-like protein KIF7

Ligandability

Cysteine 74 of Kinesin-like protein KIF7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of Kinesin-like protein KIF7

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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