R-spondin-1
Intramolecular
Cysteine 129 and cysteine 44
Cysteine 97 and cysteine 105
Cysteine 129 and cysteine 142
Cysteine 114 and cysteine 125
Cysteine 79 and cysteine 94
Cysteine 102 and cysteine 111
Cysteine 40 and cysteine 47
Cysteine 56 and cysteine 75
Cysteine 44 and cysteine 53
Cysteine 97 and cysteine 102
More...Cysteine 102 and cysteine 105
Cysteine 53 and cysteine 75
Cysteine 111 and cysteine 114
Cysteine 111 and cysteine 125
Cysteine 47 and cysteine 53
Cysteine 44 and cysteine 75
Cysteine 102 and cysteine 125
Cysteine 53 and cysteine 56
Cysteine 40 and cysteine 53
Cysteine 40 and cysteine 44
Cysteine 105 and cysteine 111
Cysteine 44 and cysteine 56
Cysteine 44 and cysteine 47
Cysteine 97 and cysteine 111
Cysteine 102 and cysteine 114
Cysteine 79 and cysteine 97
Cysteine 114 and cysteine 44
Cysteine 125 and cysteine 129
Cysteine 47 and cysteine 56
Cysteine 97 and cysteine 125
Cysteine 79 and cysteine 105
Cysteine 105 and cysteine 114
Cysteine 105 and cysteine 125
Cysteine 40 and cysteine 75
Cysteine 56 and cysteine 94
Cysteine 56 and cysteine 79
Cysteine 94 and cysteine 97
Cysteine 75 and cysteine 94
Cysteine 114 and cysteine 142
Cysteine 114 and cysteine 129
4kng P 129 P 142
A redox-regulated disulphide may form within R-spondin-1 between cysteines 129 and 44 (129 and 142 respectively in this structure).
Details
Redox score ?
92
PDB code
4kng
Structure name
crystal structure of human lgr5-rspo1-rnf43
Structure deposition date
2013-05-09
Thiol separation (Å)
2
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
129
Residue number B
44
Peptide name
R-spondin-1
Ligandability
Cysteine 129 of R-spondin-1
Cysteine 44 of R-spondin-1
Uncertain whether structure cysteine 142 has been assigned to correct residue.
4bsu D 97 D 105
A redox-regulated disulphide may form within R-spondin-1 between cysteines 97 and 105.
Details
Redox score ?
87
PDB code
4bsu
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in c2 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
97
Residue number B
105
Peptide name
R-spondin-1
Ligandability
Cysteine 97 of R-spondin-1
Cysteine 105 of R-spondin-1
4cdk F 129 F 142
A redox-regulated disulphide may form within R-spondin-1 between cysteines 129 and 142.
Details
Redox score ?
87
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
nan
Minimum pKa ?
9
% buried
0
Peptide accession
Q2MKA7
Residue number A
129
Residue number B
142
Peptide name
R-spondin-1
Ligandability
Cysteine 129 of R-spondin-1
Cysteine 142 of R-spondin-1
4bsu D 114 D 125
A redox-regulated disulphide may form within R-spondin-1 between cysteines 114 and 125.
Details
Redox score ?
86
PDB code
4bsu
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in c2 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
63
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
114
Residue number B
125
Peptide name
R-spondin-1
Ligandability
Cysteine 114 of R-spondin-1
Cysteine 125 of R-spondin-1
4cdk G 79 G 94
A redox-regulated disulphide may form within R-spondin-1 between cysteines 79 and 94.
Details
Redox score ?
85
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
79
Residue number B
94
Peptide name
R-spondin-1
Ligandability
Cysteine 79 of R-spondin-1
Cysteine 94 of R-spondin-1
4bst C 102 C 111
A redox-regulated disulphide may form within R-spondin-1 between cysteines 102 and 111.
Details
Redox score ?
85
PDB code
4bst
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
102
Residue number B
111
Peptide name
R-spondin-1
Ligandability
Cysteine 102 of R-spondin-1
Cysteine 111 of R-spondin-1
4cdk H 40 H 47
A redox-regulated disulphide may form within R-spondin-1 between cysteines 40 and 47.
Details
Redox score ?
85
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
46
Minimum pKa ?
8
% buried
0
Peptide accession
Q2MKA7
Residue number A
40
Residue number B
47
Peptide name
R-spondin-1
Ligandability
Cysteine 40 of R-spondin-1
Cysteine 47 of R-spondin-1
4bsp A 56 A 75
A redox-regulated disulphide may form within R-spondin-1 between cysteines 56 and 75.
Details
Redox score ?
85
PDB code
4bsp
Structure name
crystal structure of r-spondin 1 (fu1fu2) - holmium soak
Structure deposition date
2013-06-11
Thiol separation (Å)
2
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
56
Residue number B
75
Peptide name
R-spondin-1
Ligandability
Cysteine 56 of R-spondin-1
Cysteine 75 of R-spondin-1
4cdk G 44 G 53
A redox-regulated disulphide may form within R-spondin-1 between cysteines 44 and 53.
Details
Redox score ?
85
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
44
Residue number B
53
Peptide name
R-spondin-1
Ligandability
Cysteine 44 of R-spondin-1
Cysteine 53 of R-spondin-1
4bso A 67 A 72
A redox-regulated disulphide may form within R-spondin-1 between cysteines 97 and 102 (67 and 72 respectively in this structure).
Details
Redox score ?
78
PDB code
4bso
Structure name
crystal structure of r-spondin 1 (fu1fu2) - native
Structure deposition date
2013-06-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
97
Residue number B
102
Peptide name
R-spondin-1
Ligandability
Cysteine 97 of R-spondin-1
Cysteine 102 of R-spondin-1
4bst D 102 D 105
A redox-regulated disulphide may form within R-spondin-1 between cysteines 102 and 105.
Details
Redox score ?
77
PDB code
4bst
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
3
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
102
Residue number B
105
Peptide name
R-spondin-1
Ligandability
Cysteine 102 of R-spondin-1
Cysteine 105 of R-spondin-1
4kng M 53 M 75
A redox-regulated disulphide may form within R-spondin-1 between cysteines 53 and 75.
Details
Redox score ?
76
PDB code
4kng
Structure name
crystal structure of human lgr5-rspo1-rnf43
Structure deposition date
2013-05-09
Thiol separation (Å)
3
Half-sphere exposure sum ?
69
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
53
Residue number B
75
Peptide name
R-spondin-1
Ligandability
Cysteine 53 of R-spondin-1
Cysteine 75 of R-spondin-1
4cdk E 111 E 114
A redox-regulated disulphide may form within R-spondin-1 between cysteines 111 and 114.
Details
Redox score ?
75
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
111
Residue number B
114
Peptide name
R-spondin-1
Ligandability
Cysteine 111 of R-spondin-1
Cysteine 114 of R-spondin-1
4li2 B 111 B 125
A redox-regulated disulphide may form within R-spondin-1 between cysteines 111 and 125.
Details
Redox score ?
75
PDB code
4li2
Structure name
crystal structures of lgr4 and its complex with r-spondin1
Structure deposition date
2013-07-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
111
Residue number B
125
Peptide name
R-spondin-1
Ligandability
Cysteine 111 of R-spondin-1
Cysteine 125 of R-spondin-1
4li2 B 47 B 53
A redox-regulated disulphide may form within R-spondin-1 between cysteines 47 and 53.
Details
Redox score ?
73
PDB code
4li2
Structure name
crystal structures of lgr4 and its complex with r-spondin1
Structure deposition date
2013-07-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
47
Residue number B
53
Peptide name
R-spondin-1
Ligandability
Cysteine 47 of R-spondin-1
Cysteine 53 of R-spondin-1
4kt1 E 44 E 75
A redox-regulated disulphide may form within R-spondin-1 between cysteines 44 and 75.
Details
Redox score ?
72
PDB code
4kt1
Structure name
complex of r-spondin 1 with lgr4 extracellular domain
Structure deposition date
2013-05-19
Thiol separation (Å)
4
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
44
Residue number B
75
Peptide name
R-spondin-1
Ligandability
Cysteine 44 of R-spondin-1
Cysteine 75 of R-spondin-1
4kt1 E 102 E 125
A redox-regulated disulphide may form within R-spondin-1 between cysteines 102 and 125.
Details
Redox score ?
72
PDB code
4kt1
Structure name
complex of r-spondin 1 with lgr4 extracellular domain
Structure deposition date
2013-05-19
Thiol separation (Å)
5
Half-sphere exposure sum ?
60
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
102
Residue number B
125
Peptide name
R-spondin-1
Ligandability
Cysteine 102 of R-spondin-1
Cysteine 125 of R-spondin-1
4bsr C 53 C 56
A redox-regulated disulphide may form within R-spondin-1 between cysteines 53 and 56.
Details
Redox score ?
70
PDB code
4bsr
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p22121 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
53
Residue number B
56
Peptide name
R-spondin-1
Ligandability
Cysteine 53 of R-spondin-1
Cysteine 56 of R-spondin-1
4li2 B 40 B 53
A redox-regulated disulphide may form within R-spondin-1 between cysteines 40 and 53.
Details
Redox score ?
68
PDB code
4li2
Structure name
crystal structures of lgr4 and its complex with r-spondin1
Structure deposition date
2013-07-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
46
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
40
Residue number B
53
Peptide name
R-spondin-1
Ligandability
Cysteine 40 of R-spondin-1
Cysteine 53 of R-spondin-1
4li2 B 40 B 44
A redox-regulated disulphide may form within R-spondin-1 between cysteines 40 and 44.
Details
Redox score ?
67
PDB code
4li2
Structure name
crystal structures of lgr4 and its complex with r-spondin1
Structure deposition date
2013-07-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
42
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
40
Residue number B
44
Peptide name
R-spondin-1
Ligandability
Cysteine 40 of R-spondin-1
Cysteine 44 of R-spondin-1
4bst D 105 D 111
A redox-regulated disulphide may form within R-spondin-1 between cysteines 105 and 111.
Details
Redox score ?
66
PDB code
4bst
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
5
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
105
Residue number B
111
Peptide name
R-spondin-1
Ligandability
Cysteine 105 of R-spondin-1
Cysteine 111 of R-spondin-1
4bss H 44 H 56
A redox-regulated disulphide may form within R-spondin-1 between cysteines 44 and 56.
Details
Redox score ?
65
PDB code
4bss
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p21 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
44
Residue number B
56
Peptide name
R-spondin-1
Ligandability
Cysteine 44 of R-spondin-1
Cysteine 56 of R-spondin-1
4cdk F 44 F 47
A redox-regulated disulphide may form within R-spondin-1 between cysteines 44 and 47.
Details
Redox score ?
64
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
6
Half-sphere exposure sum ?
50
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
44
Residue number B
47
Peptide name
R-spondin-1
Ligandability
Cysteine 44 of R-spondin-1
Cysteine 47 of R-spondin-1
4bsu D 97 D 111
A redox-regulated disulphide may form within R-spondin-1 between cysteines 97 and 111.
Details
Redox score ?
63
PDB code
4bsu
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in c2 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
97
Residue number B
111
Peptide name
R-spondin-1
Ligandability
Cysteine 97 of R-spondin-1
Cysteine 111 of R-spondin-1
4bsu H 102 H 114
A redox-regulated disulphide may form within R-spondin-1 between cysteines 102 and 114.
Details
Redox score ?
63
PDB code
4bsu
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in c2 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
6
Half-sphere exposure sum ?
65
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
102
Residue number B
114
Peptide name
R-spondin-1
Ligandability
Cysteine 102 of R-spondin-1
Cysteine 114 of R-spondin-1
4bst C 79 C 97
A redox-regulated disulphide may form within R-spondin-1 between cysteines 79 and 97. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4bst
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
79
Residue number B
97
Peptide name
R-spondin-1
Ligandability
Cysteine 79 of R-spondin-1
Cysteine 97 of R-spondin-1
4kng P 114 P 142
A redox-regulated disulphide may form within R-spondin-1 between cysteines 114 and 44 (114 and 142 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
4kng
Structure name
crystal structure of human lgr5-rspo1-rnf43
Structure deposition date
2013-05-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
nan
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
114
Residue number B
44
Peptide name
R-spondin-1
Ligandability
Cysteine 114 of R-spondin-1
Cysteine 44 of R-spondin-1
Uncertain whether structure cysteine 142 has been assigned to correct residue.
4cdk H 125 H 129
A redox-regulated disulphide may form within R-spondin-1 between cysteines 125 and 129. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
49
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
125
Residue number B
129
Peptide name
R-spondin-1
Ligandability
Cysteine 125 of R-spondin-1
Cysteine 129 of R-spondin-1
4li2 B 47 B 56
A redox-regulated disulphide may form within R-spondin-1 between cysteines 47 and 56. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
4li2
Structure name
crystal structures of lgr4 and its complex with r-spondin1
Structure deposition date
2013-07-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
53
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
47
Residue number B
56
Peptide name
R-spondin-1
Ligandability
Cysteine 47 of R-spondin-1
Cysteine 56 of R-spondin-1
4bsu H 97 H 125
A redox-regulated disulphide may form within R-spondin-1 between cysteines 97 and 125. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
4bsu
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in c2 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
97
Residue number B
125
Peptide name
R-spondin-1
Ligandability
Cysteine 97 of R-spondin-1
Cysteine 125 of R-spondin-1
4cdk H 79 H 105
A redox-regulated disulphide may form within R-spondin-1 between cysteines 79 and 105. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
79
Residue number B
105
Peptide name
R-spondin-1
Ligandability
Cysteine 79 of R-spondin-1
Cysteine 105 of R-spondin-1
4bso A 75 A 84
A redox-regulated disulphide may form within R-spondin-1 between cysteines 105 and 114 (75 and 84 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
4bso
Structure name
crystal structure of r-spondin 1 (fu1fu2) - native
Structure deposition date
2013-06-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
105
Residue number B
114
Peptide name
R-spondin-1
Ligandability
Cysteine 105 of R-spondin-1
Cysteine 114 of R-spondin-1
4bst D 105 D 125
A redox-regulated disulphide may form within R-spondin-1 between cysteines 105 and 125. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4bst
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p6122 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
105
Residue number B
125
Peptide name
R-spondin-1
Ligandability
Cysteine 105 of R-spondin-1
Cysteine 125 of R-spondin-1
4cdk E 40 E 75
A redox-regulated disulphide may form within R-spondin-1 between cysteines 40 and 75. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
40
Residue number B
75
Peptide name
R-spondin-1
Ligandability
Cysteine 40 of R-spondin-1
Cysteine 75 of R-spondin-1
4cdk G 56 G 94
A redox-regulated disulphide may form within R-spondin-1 between cysteines 56 and 94. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
56
Residue number B
94
Peptide name
R-spondin-1
Ligandability
Cysteine 56 of R-spondin-1
Cysteine 94 of R-spondin-1
4qxf E 56 E 79
A redox-regulated disulphide may form within R-spondin-1 between cysteines 56 and 79. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4qxf
Structure name
crystal structure of human lgr4 and rspo1
Structure deposition date
2014-07-20
Thiol separation (Å)
10
Half-sphere exposure sum ?
47
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
56
Residue number B
79
Peptide name
R-spondin-1
Ligandability
Cysteine 56 of R-spondin-1
Cysteine 79 of R-spondin-1
4bss C 94 C 97
A redox-regulated disulphide may form within R-spondin-1 between cysteines 94 and 97. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4bss
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p21 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
10
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
94
Residue number B
97
Peptide name
R-spondin-1
Ligandability
Cysteine 94 of R-spondin-1
Cysteine 97 of R-spondin-1
4bsr D 75 D 94
A redox-regulated disulphide may form within R-spondin-1 between cysteines 75 and 94. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4bsr
Structure name
structure of the ectodomain of lgr5 in complex with r-spondin-1 (fu1fu2) in p22121 crystal form
Structure deposition date
2013-06-11
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
75
Residue number B
94
Peptide name
R-spondin-1
Ligandability
Cysteine 75 of R-spondin-1
Cysteine 94 of R-spondin-1
4cdk G 114 G 142
A redox-regulated disulphide may form within R-spondin-1 between cysteines 114 and 142. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
9
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
114
Residue number B
142
Peptide name
R-spondin-1
Ligandability
Cysteine 114 of R-spondin-1
Cysteine 142 of R-spondin-1
4cdk E 114 E 129
A redox-regulated disulphide may form within R-spondin-1 between cysteines 114 and 129. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
44
PDB code
4cdk
Structure name
structure of znrf3-rspo1
Structure deposition date
2013-11-01
Thiol separation (Å)
10
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q2MKA7
Residue number A
114
Residue number B
129
Peptide name
R-spondin-1
Ligandability
Cysteine 114 of R-spondin-1
Cysteine 129 of R-spondin-1
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