CST complex subunit CTC1
Intramolecular
Cysteine 1046 and cysteine 1062
Cysteine 424 and cysteine 535
Cysteine 1043 and cysteine 1062
Cysteine 1050 and cysteine 1055
Cysteine 848 and cysteine 851
Cysteine 1088 and cysteine 1198
Cysteine 908 and cysteine 82
Cysteine 1043 and cysteine 1055
Cysteine 1043 and cysteine 1046
Cysteine 1043 and cysteine 1050
More...Cysteine 1046 and cysteine 1055
Cysteine 1050 and cysteine 1062
Cysteine 1046 and cysteine 1050
Cysteine 908 and cysteine 928
Cysteine 1055 and cysteine 1062
Cysteine 1029 and cysteine 1198
Cysteine 82 and cysteine 985
Cysteine 747 and cysteine 848
Cysteine 928 and cysteine 985
Cysteine 81 and cysteine 82
Cysteine 747 and cysteine 851
Cysteine 479 and cysteine 482
Cysteine 620 and cysteine 632
Cysteine 584 and cysteine 1046 L
Cysteine 837 and cysteine 851
Cysteine 984 and cysteine 985
Cysteine 1029 and cysteine 1088
8d0k A 1046 A 1062
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1046 and 1062.
Details
Redox score ?
86
PDB code
8d0k
Structure name
human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template - prim2c advanced pic
Structure deposition date
2022-05-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
53
Minimum pKa ?
6
% buried
9
Peptide accession
Q2NKJ3
Residue number A
1046
Residue number B
1062
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1046 of CST complex subunit CTC1
Cysteine 1062 of CST complex subunit CTC1
7u5c E 424 E 535
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 424 and 535.
Details
Redox score ?
84
PDB code
7u5c
Structure name
cryo-em structure of human cst bound to dna polymerase alpha-primase in a recruitment state
Structure deposition date
2022-03-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
4
% buried
70
Peptide accession
Q2NKJ3
Residue number A
424
Residue number B
535
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 424 of CST complex subunit CTC1
Cysteine 535 of CST complex subunit CTC1
8d0b A 1043 A 1062
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1043 and 1062.
Details
Redox score ?
82
PDB code
8d0b
Structure name
human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template
Structure deposition date
2022-05-26
Thiol separation (Å)
3
Half-sphere exposure sum ?
60
Minimum pKa ?
9
% buried
16
Peptide accession
Q2NKJ3
Residue number A
1043
Residue number B
1062
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1043 of CST complex subunit CTC1
Cysteine 1062 of CST complex subunit CTC1
7u5c E 1050 E 1055
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1050 and 1055.
Details
Redox score ?
82
PDB code
7u5c
Structure name
cryo-em structure of human cst bound to dna polymerase alpha-primase in a recruitment state
Structure deposition date
2022-03-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
6
% buried
16
Peptide accession
Q2NKJ3
Residue number A
1050
Residue number B
1055
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1050 of CST complex subunit CTC1
Cysteine 1055 of CST complex subunit CTC1
5w2l A 848 A 851
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 848 and 851.
Details
Redox score ?
80
PDB code
5w2l
Structure name
structure of a central domain of human ctc1
Structure deposition date
2017-06-06
Thiol separation (Å)
4
Half-sphere exposure sum ?
47
Minimum pKa ?
7
% buried
25
Peptide accession
Q2NKJ3
Residue number A
848
Residue number B
851
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 848 of CST complex subunit CTC1
Cysteine 851 of CST complex subunit CTC1
7u5c E 1088 E 1198
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1088 and 1198.
Details
Redox score ?
79
PDB code
7u5c
Structure name
cryo-em structure of human cst bound to dna polymerase alpha-primase in a recruitment state
Structure deposition date
2022-03-02
Thiol separation (Å)
4
Half-sphere exposure sum ?
66
Minimum pKa ?
5
% buried
78
Peptide accession
Q2NKJ3
Residue number A
1088
Residue number B
1198
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1088 of CST complex subunit CTC1
Cysteine 1198 of CST complex subunit CTC1
6w6w A 908 A 928
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 908 and 82 (908 and 928 respectively in this structure).
Details
Redox score ?
77
PDB code
6w6w
Structure name
cryo-em structure of cst bound to telomeric single-stranded dna
Structure deposition date
2020-03-17
Thiol separation (Å)
5
Half-sphere exposure sum ?
nan
Minimum pKa ?
10
% buried
41
Peptide accession
Q2NKJ3
Residue number A
908
Residue number B
82
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 908 of CST complex subunit CTC1
Cysteine 82 of CST complex subunit CTC1
8d0k A 1043 A 1055
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1043 and 1055.
Details
Redox score ?
75
PDB code
8d0k
Structure name
human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template - prim2c advanced pic
Structure deposition date
2022-05-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
9
% buried
25
Peptide accession
Q2NKJ3
Residue number A
1043
Residue number B
1055
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1043 of CST complex subunit CTC1
Cysteine 1055 of CST complex subunit CTC1
6w6w A 1043 A 1046
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1043 and 1046.
Details
Redox score ?
73
PDB code
6w6w
Structure name
cryo-em structure of cst bound to telomeric single-stranded dna
Structure deposition date
2020-03-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
63
Minimum pKa ?
8
% buried
11
Peptide accession
Q2NKJ3
Residue number A
1043
Residue number B
1046
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1043 of CST complex subunit CTC1
Cysteine 1046 of CST complex subunit CTC1
6w6w A 1043 A 1050
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1043 and 1050.
Details
Redox score ?
72
PDB code
6w6w
Structure name
cryo-em structure of cst bound to telomeric single-stranded dna
Structure deposition date
2020-03-17
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
9
% buried
26
Peptide accession
Q2NKJ3
Residue number A
1043
Residue number B
1050
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1043 of CST complex subunit CTC1
Cysteine 1050 of CST complex subunit CTC1
7u5c E 1046 E 1055
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1046 and 1055.
Details
Redox score ?
71
PDB code
7u5c
Structure name
cryo-em structure of human cst bound to dna polymerase alpha-primase in a recruitment state
Structure deposition date
2022-03-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
6
% buried
0
Peptide accession
Q2NKJ3
Residue number A
1046
Residue number B
1055
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1046 of CST complex subunit CTC1
Cysteine 1055 of CST complex subunit CTC1
8d0b A 1050 A 1062
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1050 and 1062.
Details
Redox score ?
62
PDB code
8d0b
Structure name
human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template
Structure deposition date
2022-05-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
58
Minimum pKa ?
9
% buried
18
Peptide accession
Q2NKJ3
Residue number A
1050
Residue number B
1062
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1050 of CST complex subunit CTC1
Cysteine 1062 of CST complex subunit CTC1
8d0k A 1046 A 1050
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1046 and 1050.
Details
Redox score ?
61
PDB code
8d0k
Structure name
human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template - prim2c advanced pic
Structure deposition date
2022-05-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
6
% buried
30
Peptide accession
Q2NKJ3
Residue number A
1046
Residue number B
1050
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1046 of CST complex subunit CTC1
Cysteine 1050 of CST complex subunit CTC1
8d0k A 908 A 928
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 908 and 928. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
60
PDB code
8d0k
Structure name
human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template - prim2c advanced pic
Structure deposition date
2022-05-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
50
Minimum pKa ?
9
% buried
38
Peptide accession
Q2NKJ3
Residue number A
908
Residue number B
928
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 908 of CST complex subunit CTC1
Cysteine 928 of CST complex subunit CTC1
7u5c E 1055 E 1062
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1055 and 1062. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
58
PDB code
7u5c
Structure name
cryo-em structure of human cst bound to dna polymerase alpha-primase in a recruitment state
Structure deposition date
2022-03-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
6
% buried
2
Peptide accession
Q2NKJ3
Residue number A
1055
Residue number B
1062
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1055 of CST complex subunit CTC1
Cysteine 1062 of CST complex subunit CTC1
7u5c E 1029 E 1198
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1029 and 1198. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
52
PDB code
7u5c
Structure name
cryo-em structure of human cst bound to dna polymerase alpha-primase in a recruitment state
Structure deposition date
2022-03-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
71
Minimum pKa ?
5
% buried
89
Peptide accession
Q2NKJ3
Residue number A
1029
Residue number B
1198
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1029 of CST complex subunit CTC1
Cysteine 1198 of CST complex subunit CTC1
6w6w A 928 A 985
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 82 and 985 (928 and 985 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
51
PDB code
6w6w
Structure name
cryo-em structure of cst bound to telomeric single-stranded dna
Structure deposition date
2020-03-17
Thiol separation (Å)
8
Half-sphere exposure sum ?
nan
Minimum pKa ?
11
% buried
48
Peptide accession
Q2NKJ3
Residue number A
82
Residue number B
985
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 82 of CST complex subunit CTC1
Cysteine 985 of CST complex subunit CTC1
5w2l B 747 B 848
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 747 and 848. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
5w2l
Structure name
structure of a central domain of human ctc1
Structure deposition date
2017-06-06
Thiol separation (Å)
10
Half-sphere exposure sum ?
42
Minimum pKa ?
7
% buried
14
Peptide accession
Q2NKJ3
Residue number A
747
Residue number B
848
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 747 of CST complex subunit CTC1
Cysteine 848 of CST complex subunit CTC1
8d0b A 928 A 985
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 928 and 985. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
47
PDB code
8d0b
Structure name
human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template
Structure deposition date
2022-05-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
57
Minimum pKa ?
10
% buried
61
Peptide accession
Q2NKJ3
Residue number A
928
Residue number B
985
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 928 of CST complex subunit CTC1
Cysteine 985 of CST complex subunit CTC1
8d0k A 81 A 82
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 81 and 82. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
8d0k
Structure name
human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template - prim2c advanced pic
Structure deposition date
2022-05-26
Thiol separation (Å)
7
Half-sphere exposure sum ?
64
Minimum pKa ?
11
% buried
73
Peptide accession
Q2NKJ3
Residue number A
81
Residue number B
82
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 81 of CST complex subunit CTC1
Cysteine 82 of CST complex subunit CTC1
5w2l A 747 A 851
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 747 and 851. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
46
PDB code
5w2l
Structure name
structure of a central domain of human ctc1
Structure deposition date
2017-06-06
Thiol separation (Å)
9
Half-sphere exposure sum ?
55
Minimum pKa ?
10
% buried
24
Peptide accession
Q2NKJ3
Residue number A
747
Residue number B
851
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 747 of CST complex subunit CTC1
Cysteine 851 of CST complex subunit CTC1
8d0b A 479 A 482
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 479 and 482. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
45
PDB code
8d0b
Structure name
human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template
Structure deposition date
2022-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
50
Minimum pKa ?
10
% buried
37
Peptide accession
Q2NKJ3
Residue number A
479
Residue number B
482
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 479 of CST complex subunit CTC1
Cysteine 482 of CST complex subunit CTC1
8d0b A 620 A 632
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 620 and 632. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
8d0b
Structure name
human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template
Structure deposition date
2022-05-26
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
10
% buried
66
Peptide accession
Q2NKJ3
Residue number A
620
Residue number B
632
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 620 of CST complex subunit CTC1
Cysteine 632 of CST complex subunit CTC1
6w6w A 584 A 1046
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 584 and 1046. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
41
PDB code
6w6w
Structure name
cryo-em structure of cst bound to telomeric single-stranded dna
Structure deposition date
2020-03-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
51
Minimum pKa ?
8
% buried
8
Peptide accession
Q2NKJ3
Residue number A
584
Residue number B
1046
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 584 of CST complex subunit CTC1
Cysteine 1046 of CST complex subunit CTC1
7u5c E 837 E 851
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 837 and 851. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
7u5c
Structure name
cryo-em structure of human cst bound to dna polymerase alpha-primase in a recruitment state
Structure deposition date
2022-03-02
Thiol separation (Å)
9
Half-sphere exposure sum ?
54
Minimum pKa ?
10
% buried
42
Peptide accession
Q2NKJ3
Residue number A
837
Residue number B
851
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 837 of CST complex subunit CTC1
Cysteine 851 of CST complex subunit CTC1
8d0k A 984 A 985
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 984 and 985. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
40
PDB code
8d0k
Structure name
human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback template - prim2c advanced pic
Structure deposition date
2022-05-26
Thiol separation (Å)
8
Half-sphere exposure sum ?
66
Minimum pKa ?
11
% buried
82
Peptide accession
Q2NKJ3
Residue number A
984
Residue number B
985
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 984 of CST complex subunit CTC1
Cysteine 985 of CST complex subunit CTC1
6w6w A 1029 A 1088
A redox-regulated disulphide may form within CST complex subunit CTC1 between cysteines 1029 and 1088. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
27
PDB code
6w6w
Structure name
cryo-em structure of cst bound to telomeric single-stranded dna
Structure deposition date
2020-03-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
75
Minimum pKa ?
13
% buried
94
Peptide accession
Q2NKJ3
Residue number A
1029
Residue number B
1088
Peptide name
CST complex subunit CTC1
Ligandability
Cysteine 1029 of CST complex subunit CTC1
Cysteine 1088 of CST complex subunit CTC1
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