a tool for identifying drug-targetable redox-active disulphides

PWWP domain-containing DNA repair factor 3A

Intermolecular

Cysteine 501 and cysteine 501

A redox-regulated disulphide may form between two units of PWWP domain-containing DNA repair factor 3A at cysteines 501 and 501 (502 and 502 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

41

PDB code

Structure name

pwwp domain of human mutated melanoma-associated antigen 1

Structure deposition date

2010-11-17

Thiol separation (Å)

9

Half-sphere exposure sum ?

56

Minimum pK_a ?

10

% buried

nan

Peptide A name

PWWP domain-containing DNA repair factor 3A

Peptide B name

PWWP domain-containing DNA repair factor 3A

Peptide A accession

Peptide B accession

Peptide A residue number

501

Peptide B residue number

501

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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