CWF19-like protein 2
Intramolecular
Cysteine 711 and cysteine 770
Cysteine 675 and cysteine 678
Cysteine 751 and cysteine 770
Cysteine 711 and cysteine 751
Cysteine 699 and cysteine 711
6id1 U 711 U 770
A redox-regulated disulphide may form within CWF19-like protein 2 between cysteines 711 and 770.
Details
Redox score ?
66
PDB code
6id1
Structure name
cryo-em structure of a human intron lariat spliceosome after prp43 loaded (ils2 complex) at 2
Structure deposition date
2018-09-07
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
10
% buried
100
Peptide accession
Q2TBE0
Residue number A
711
Residue number B
770
Peptide name
CWF19-like protein 2
Ligandability
Cysteine 711 of CWF19-like protein 2
Cysteine 770 of CWF19-like protein 2
6id0 U 675 U 678
A redox-regulated disulphide may form within CWF19-like protein 2 between cysteines 675 and 678.
Details
Redox score ?
64
PDB code
6id0
Structure name
cryo-em structure of a human intron lariat spliceosome prior to prp43 loaded (ils1 complex) at 2
Structure deposition date
2018-09-07
Thiol separation (Å)
5
Half-sphere exposure sum ?
65
Minimum pKa ?
10
% buried
80
Peptide accession
Q2TBE0
Residue number A
675
Residue number B
678
Peptide name
CWF19-like protein 2
Ligandability
Cysteine 675 of CWF19-like protein 2
Cysteine 678 of CWF19-like protein 2
6id1 U 751 U 770
A redox-regulated disulphide may form within CWF19-like protein 2 between cysteines 751 and 770.
Details
Redox score ?
61
PDB code
6id1
Structure name
cryo-em structure of a human intron lariat spliceosome after prp43 loaded (ils2 complex) at 2
Structure deposition date
2018-09-07
Thiol separation (Å)
5
Half-sphere exposure sum ?
89
Minimum pKa ?
9
% buried
94
Peptide accession
Q2TBE0
Residue number A
751
Residue number B
770
Peptide name
CWF19-like protein 2
Ligandability
Cysteine 751 of CWF19-like protein 2
Cysteine 770 of CWF19-like protein 2
6id1 U 711 U 751
A redox-regulated disulphide may form within CWF19-like protein 2 between cysteines 711 and 751. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
43
PDB code
6id1
Structure name
cryo-em structure of a human intron lariat spliceosome after prp43 loaded (ils2 complex) at 2
Structure deposition date
2018-09-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
87
Minimum pKa ?
9
% buried
94
Peptide accession
Q2TBE0
Residue number A
711
Residue number B
751
Peptide name
CWF19-like protein 2
Ligandability
Cysteine 711 of CWF19-like protein 2
Cysteine 751 of CWF19-like protein 2
6id1 U 699 U 711
A redox-regulated disulphide may form within CWF19-like protein 2 between cysteines 699 and 711. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
6id1
Structure name
cryo-em structure of a human intron lariat spliceosome after prp43 loaded (ils2 complex) at 2
Structure deposition date
2018-09-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
10
% buried
98
Peptide accession
Q2TBE0
Residue number A
699
Residue number B
711
Peptide name
CWF19-like protein 2
Ligandability
Cysteine 699 of CWF19-like protein 2
Cysteine 711 of CWF19-like protein 2
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