MHC class II HLA-DQ-alpha chain
Intermolecular
Cysteine 11 and cysteine 47 of MHC class II antigen
Cysteine 11 and cysteine 47 of MHC class II antigen
Cysteine 11 and cysteine 111 of MHC class II antigen
Cysteine 11 and cysteine 111 of MHC class II antigen
Intramolecular
Cysteine 110 and cysteine 166
3pl6 A 8 B 15
A redox-regulated disulphide may form between cysteine 11 of MHC class II HLA-DQ-alpha chain and cysteine 47 of MHC class II antigen (8 and 15 respectively in this structure).
Details
Redox score ?
63
PDB code
3pl6
Structure name
structure of autoimmune tcr hy
Structure deposition date
2010-11-13
Thiol separation (Å)
3
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
nan
Peptide A name
MHC class II HLA-DQ-alpha chain
Peptide B name
MHC class II antigen
Peptide A accession
Q30066
Peptide B accession
Q67AJ6
Peptide A residue number
11
Peptide B residue number
47
Ligandability
Cysteine 11 of MHC class II HLA-DQ-alpha chain
Cysteine 47 of MHC class II antigen
6dig A 11 B 15
A redox-regulated disulphide may form between cysteine 11 of MHC class II HLA-DQ-alpha chain and cysteine 47 of MHC class II antigen (11 and 15 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
56
PDB code
6dig
Structure name
crystal structure of dqa1*01:02/dqb1*06:02 in complex with a hypocretin peptide
Structure deposition date
2018-05-23
Thiol separation (Å)
4
Half-sphere exposure sum ?
96
Minimum pKa ?
12
% buried
nan
Peptide A name
MHC class II HLA-DQ-alpha chain
Peptide B name
MHC class II antigen
Peptide A accession
Q30066
Peptide B accession
Q5SU54
Peptide A residue number
11
Peptide B residue number
47
Ligandability
Cysteine 11 of MHC class II HLA-DQ-alpha chain
Cysteine 47 of MHC class II antigen
4may A 8 B 79
A redox-regulated disulphide may form between cysteine 11 of MHC class II HLA-DQ-alpha chain and cysteine 111 of MHC class II antigen (8 and 79 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
55
PDB code
4may
Structure name
crystal structure of an immune complex
Structure deposition date
2013-08-18
Thiol separation (Å)
5
Half-sphere exposure sum ?
93
Minimum pKa ?
12
% buried
nan
Peptide A name
MHC class II HLA-DQ-alpha chain
Peptide B name
MHC class II antigen
Peptide A accession
Q30066
Peptide B accession
Q67AJ6
Peptide A residue number
11
Peptide B residue number
111
Ligandability
Cysteine 11 of MHC class II HLA-DQ-alpha chain
Cysteine 111 of MHC class II antigen
6dig A 11 B 79
A redox-regulated disulphide may form between cysteine 11 of MHC class II HLA-DQ-alpha chain and cysteine 111 of MHC class II antigen (11 and 79 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
48
PDB code
6dig
Structure name
crystal structure of dqa1*01:02/dqb1*06:02 in complex with a hypocretin peptide
Structure deposition date
2018-05-23
Thiol separation (Å)
6
Half-sphere exposure sum ?
91
Minimum pKa ?
12
% buried
nan
Peptide A name
MHC class II HLA-DQ-alpha chain
Peptide B name
MHC class II antigen
Peptide A accession
Q30066
Peptide B accession
Q5SU54
Peptide A residue number
11
Peptide B residue number
111
Ligandability
Cysteine 11 of MHC class II HLA-DQ-alpha chain
Cysteine 111 of MHC class II antigen
4may A 107 A 163
A redox-regulated disulphide may form within MHC class II HLA-DQ-alpha chain between cysteines 110 and 166 (107 and 163 respectively in this structure).
Details
Redox score ?
80
PDB code
4may
Structure name
crystal structure of an immune complex
Structure deposition date
2013-08-18
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q30066
Residue number A
110
Residue number B
166
Peptide name
MHC class II HLA-DQ-alpha chain
Ligandability
Cysteine 110 of MHC class II HLA-DQ-alpha chain
Cysteine 166 of MHC class II HLA-DQ-alpha chain
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