ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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HLA class II histocompatibility antigen, DR beta 5 chain

Intramolecular
Cysteine 146 and cysteine 202
Cysteine 44 and cysteine 108
A redox-regulated disulphide may form within HLA class II histocompatibility antigen, DR beta 5 chain between cysteines 146 and 202 (117 and 173 respectively in this structure).

Details

Redox score ?
79
PDB code
1h15
Structure name
x-ray crystal structure of hla-dra1*0101/drb5*0101 complexed with a peptide from epstein barr virus dna polymerase
Structure deposition date
2002-07-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q30126
Residue number A
146
Residue number B
202
Peptide name
HLA class II histocompatibility antigen, DR beta 5 chain

Ligandability

Cysteine 146 of HLA class II histocompatibility antigen, DR beta 5 chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 202 of HLA class II histocompatibility antigen, DR beta 5 chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within HLA class II histocompatibility antigen, DR beta 5 chain between cysteines 44 and 108 (215 and 279 respectively in this structure).

Details

Redox score ?
77
PDB code
1hqr
Structure name
crystal structure of a superantigen bound to the high- affinity, zinc-dependent site on mhc class ii
Structure deposition date
2000-12-19
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q29703
Residue number A
44
Residue number B
108
Peptide name
HLA class II histocompatibility antigen, DR beta 5 chain

Ligandability

Cysteine 44 of HLA class II histocompatibility antigen, DR beta 5 chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of HLA class II histocompatibility antigen, DR beta 5 chain

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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