ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Hereditary hemochromatosis protein

Intramolecular
Cysteine 124 and cysteine 187
Cysteine 225 and cysteine 282
A redox-regulated disulphide may form within Hereditary hemochromatosis protein between cysteines 124 and 187 (102 and 165 respectively in this structure).

Details

Redox score ?
83
PDB code
1a6z
Structure name
hfe (human) hemochromatosis protein
Structure deposition date
1998-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q30201
Residue number A
124
Residue number B
187
Peptide name
Hereditary hemochromatosis protein

Ligandability

Cysteine 124 of Hereditary hemochromatosis protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 187 of Hereditary hemochromatosis protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Hereditary hemochromatosis protein between cysteines 225 and 282 (203 and 260 respectively in this structure).

Details

Redox score ?
80
PDB code
1de4
Structure name
hemochromatosis protein hfe complexed with transferrin receptor
Structure deposition date
1999-11-12
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q30201
Residue number A
225
Residue number B
282
Peptide name
Hereditary hemochromatosis protein

Ligandability

Cysteine 225 of Hereditary hemochromatosis protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 282 of Hereditary hemochromatosis protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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