ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class I Mamu-A*02

Intramolecular
Cysteine 117 and cysteine 180
Cysteine 219 and cysteine 275
A redox-regulated disulphide may form within MHC class I Mamu-A*02 between cysteines 117 and 180 (101 and 164 respectively in this structure).

Details

Redox score ?
84
PDB code
3jts
Structure name
gy9-mamu-a*02-hb2m
Structure deposition date
2009-09-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
76
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q30597
Residue number A
117
Residue number B
180
Peptide name
MHC class I Mamu-A*02

Ligandability

Cysteine 117 of MHC class I Mamu-A*02

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 180 of MHC class I Mamu-A*02

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class I Mamu-A*02 between cysteines 219 and 275 (203 and 259 respectively in this structure).

Details

Redox score ?
80
PDB code
3jtt
Structure name
cystal structure of rhesus macaque mhc class i:mamu-a*02
Structure deposition date
2009-09-14
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q30597
Residue number A
219
Residue number B
275
Peptide name
MHC class I Mamu-A*02

Ligandability

Cysteine 219 of MHC class I Mamu-A*02

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 275 of MHC class I Mamu-A*02

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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