ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

H2-Ab1 protein

Intramolecular
Cysteine 143 and cysteine 199
Cysteine 42 and cysteine 104
A redox-regulated disulphide may form within H2-Ab1 protein between cysteines 143 and 199 (117 and 173 respectively in this structure).

Details

Redox score ?
79
PDB code
1f3j
Structure name
histocompatibility antigen i-ag7
Structure deposition date
2000-06-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31135
Residue number A
143
Residue number B
199
Peptide name
H2-Ab1 protein

Ligandability

Cysteine 143 of H2-Ab1 protein

Cysteine 199 of H2-Ab1 protein

A redox-regulated disulphide may form within H2-Ab1 protein between cysteines 42 and 104 (256 and 318 respectively in this structure).

Details

Redox score ?
79
PDB code
3cup
Structure name
crystal structure of the mhc class ii molecule i-ag7 in complex with the peptide gad221-235
Structure deposition date
2008-04-16
Thiol separation (Å)
2
Half-sphere exposure sum ?
89
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31135
Residue number A
42
Residue number B
104
Peptide name
H2-Ab1 protein

Ligandability

Cysteine 42 of H2-Ab1 protein

Cysteine 104 of H2-Ab1 protein

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