ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Home
About
List

H2-T23 protein

Intramolecular
Cysteine 121 and cysteine 184
Cysteine 223 and cysteine 279
A redox-regulated disulphide may form within H2-T23 protein between cysteines 121 and 184 (101 and 164 respectively in this structure).

Details

Redox score ?
82
PDB code
5vcl
Structure name
structure of the qdm peptide bound to qa-1a
Structure deposition date
2017-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
83
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31153
Residue number A
121
Residue number B
184
Peptide name
H2-T23 protein

Ligandability

Cysteine 121 of H2-T23 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 184 of H2-T23 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within H2-T23 protein between cysteines 223 and 279 (203 and 259 respectively in this structure).

Details

Redox score ?
80
PDB code
5vcl
Structure name
structure of the qdm peptide bound to qa-1a
Structure deposition date
2017-03-31
Thiol separation (Å)
2
Half-sphere exposure sum ?
82
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31153
Residue number A
223
Residue number B
279
Peptide name
H2-T23 protein

Ligandability

Cysteine 223 of H2-T23 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 279 of H2-T23 protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

If this tool was useful for finding a disulphide, please cite: