ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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MHC class II antigen IEk-beta

Intramolecular
Cysteine 143 and cysteine 199
Cysteine 41 and cysteine 105
A redox-regulated disulphide may form within MHC class II antigen IEk-beta between cysteines 143 and 199 (117 and 173 respectively in this structure).

Details

Redox score ?
80
PDB code
1iea
Structure name
histocompatibility antigen
Structure deposition date
1996-04-05
Thiol separation (Å)
2
Half-sphere exposure sum ?
79
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31163
Residue number A
143
Residue number B
199
Peptide name
MHC class II antigen IEk-beta

Ligandability

Cysteine 143 of MHC class II antigen IEk-beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 199 of MHC class II antigen IEk-beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within MHC class II antigen IEk-beta between cysteines 41 and 105 (15 and 79 respectively in this structure).

Details

Redox score ?
78
PDB code
4p2q
Structure name
crystal structure of the 5cc7 tcr in complex with 5c2/i-ek
Structure deposition date
2014-03-04
Thiol separation (Å)
2
Half-sphere exposure sum ?
87
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31163
Residue number A
41
Residue number B
105
Peptide name
MHC class II antigen IEk-beta

Ligandability

Cysteine 41 of MHC class II antigen IEk-beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 105 of MHC class II antigen IEk-beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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