ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ig-like domain-containing protein

Intramolecular
Cysteine 117 and cysteine 173
Cysteine 15 and cysteine 79
A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 117 and 173 (144 and 200 respectively in this structure).

Details

Redox score ?
80
PDB code
1r5w
Structure name
evidence that structural rearrangements and/or flexibility during tcr binding can contribute to t-cell activation
Structure deposition date
2003-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31164
Residue number A
117
Residue number B
173
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 117 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 173 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 15 and 79 (42 and 106 respectively in this structure).

Details

Redox score ?
79
PDB code
1r5w
Structure name
evidence that structural rearrangements and/or flexibility during tcr binding can contribute to t-cell activation
Structure deposition date
2003-10-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31164
Residue number A
15
Residue number B
79
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 15 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 79 of Ig-like domain-containing protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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