ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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H-2D cell surface glycoprotein

Intramolecular
Cysteine 202 and cysteine 258
Cysteine 100 and cysteine 163
A redox-regulated disulphide may form within H-2D cell surface glycoprotein between cysteines 202 and 258 (203 and 259 respectively in this structure).

Details

Redox score ?
82
PDB code
6h6h
Structure name
crystal structures of the murine class i major histocompatibility complex h-2dbm13 in complex with adenovirus-derived peptide ad10
Structure deposition date
2018-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
84
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31167
Residue number A
202
Residue number B
258
Peptide name
H-2D cell surface glycoprotein

Ligandability

Cysteine 202 of H-2D cell surface glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of H-2D cell surface glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within H-2D cell surface glycoprotein between cysteines 100 and 163 (101 and 164 respectively in this structure).

Details

Redox score ?
82
PDB code
6h6h
Structure name
crystal structures of the murine class i major histocompatibility complex h-2dbm13 in complex with adenovirus-derived peptide ad10
Structure deposition date
2018-07-27
Thiol separation (Å)
2
Half-sphere exposure sum ?
81
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31167
Residue number A
100
Residue number B
163
Peptide name
H-2D cell surface glycoprotein

Ligandability

Cysteine 100 of H-2D cell surface glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 163 of H-2D cell surface glycoprotein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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