ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Ig-like domain-containing protein

Intramolecular
Cysteine 135 and cysteine 158
Cysteine 126 and cysteine 176
Cysteine 215 and cysteine 271
Cysteine 126 and cysteine 135
Cysteine 126 and cysteine 158
Cysteine 158 and cysteine 176
Cysteine 135 and cysteine 176
A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 135 and 158 (5110 and 5133 respectively in this structure).

Details

Redox score ?
88
PDB code
1r3h
Structure name
crystal structure of t10
Structure deposition date
2003-10-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31206
Residue number A
135
Residue number B
158
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 135 of Ig-like domain-containing protein

Cysteine 158 of Ig-like domain-containing protein

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 126 and 176 (1101 and 1164 respectively in this structure).

Details

Redox score ?
83
PDB code
1r3h
Structure name
crystal structure of t10
Structure deposition date
2003-10-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
72
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31206
Residue number A
126
Residue number B
176
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 126 of Ig-like domain-containing protein

Cysteine 176 of Ig-like domain-containing protein

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 215 and 271 (5203 and 5259 respectively in this structure).

Details

Redox score ?
80
PDB code
1r3h
Structure name
crystal structure of t10
Structure deposition date
2003-10-02
Thiol separation (Å)
2
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31206
Residue number A
215
Residue number B
271
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 215 of Ig-like domain-containing protein

Cysteine 271 of Ig-like domain-containing protein

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 126 and 135 (5101 and 5110 respectively in this structure).

Details

Redox score ?
68
PDB code
1r3h
Structure name
crystal structure of t10
Structure deposition date
2003-10-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
67
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31206
Residue number A
126
Residue number B
135
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 126 of Ig-like domain-containing protein

Cysteine 135 of Ig-like domain-containing protein

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 126 and 158 (7101 and 7133 respectively in this structure).

Details

Redox score ?
66
PDB code
1r3h
Structure name
crystal structure of t10
Structure deposition date
2003-10-02
Thiol separation (Å)
5
Half-sphere exposure sum ?
58
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31206
Residue number A
126
Residue number B
158
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 126 of Ig-like domain-containing protein

Cysteine 158 of Ig-like domain-containing protein

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 158 and 176 (7133 and 7164 respectively in this structure).

Details

Redox score ?
62
PDB code
1r3h
Structure name
crystal structure of t10
Structure deposition date
2003-10-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
57
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31206
Residue number A
158
Residue number B
176
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 158 of Ig-like domain-containing protein

Cysteine 176 of Ig-like domain-containing protein

A redox-regulated disulphide may form within Ig-like domain-containing protein between cysteines 135 and 176 (1110 and 1164 respectively in this structure).

Details

Redox score ?
61
PDB code
1r3h
Structure name
crystal structure of t10
Structure deposition date
2003-10-02
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q31206
Residue number A
135
Residue number B
176
Peptide name
Ig-like domain-containing protein

Ligandability

Cysteine 135 of Ig-like domain-containing protein

Cysteine 176 of Ig-like domain-containing protein

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