ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Bardet-Biedl syndrome 2 protein homolog

Intramolecular
Cysteine 210 and cysteine 258
Cysteine 307 and cysteine 308
Cysteine 169 and cysteine 210
A redox-regulated disulphide may form within Bardet-Biedl syndrome 2 protein homolog between cysteines 210 and 258. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
6vbv
Structure name
structure of the bovine bbsome:arl6:gtp complex
Structure deposition date
2019-12-19
Thiol separation (Å)
8
Half-sphere exposure sum ?
70
Minimum pKa ?
10
% buried
76
Peptide accession
Q32L13
Residue number A
210
Residue number B
258
Peptide name
Bardet-Biedl syndrome 2 protein homolog

Ligandability

Cysteine 210 of Bardet-Biedl syndrome 2 protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 258 of Bardet-Biedl syndrome 2 protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bardet-Biedl syndrome 2 protein homolog between cysteines 307 and 308. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
6vbu
Structure name
structure of the bovine bbsome complex
Structure deposition date
2019-12-19
Thiol separation (Å)
7
Half-sphere exposure sum ?
106
Minimum pKa ?
12
% buried
100
Peptide accession
Q32L13
Residue number A
307
Residue number B
308
Peptide name
Bardet-Biedl syndrome 2 protein homolog

Ligandability

Cysteine 307 of Bardet-Biedl syndrome 2 protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of Bardet-Biedl syndrome 2 protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Bardet-Biedl syndrome 2 protein homolog between cysteines 169 and 210. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
6vbu
Structure name
structure of the bovine bbsome complex
Structure deposition date
2019-12-19
Thiol separation (Å)
9
Half-sphere exposure sum ?
79
Minimum pKa ?
11
% buried
85
Peptide accession
Q32L13
Residue number A
169
Residue number B
210
Peptide name
Bardet-Biedl syndrome 2 protein homolog

Ligandability

Cysteine 169 of Bardet-Biedl syndrome 2 protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 210 of Bardet-Biedl syndrome 2 protein homolog

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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