ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Ribonuclease inhibitor

Intramolecular
Cysteine 324 and cysteine 325
Cysteine 268 and cysteine 272
Cysteine 325 and cysteine 375
Cysteine 272 and cysteine 308
Cysteine 90 and cysteine 91
Cysteine 300 and cysteine 324
Cysteine 7 and cysteine 33
Cysteine 40 and cysteine 90
Cysteine 211 and cysteine 215
Cysteine 300 and cysteine 325
More...
Cysteine 243 and cysteine 272
Cysteine 154 and cysteine 204
Cysteine 272 and cysteine 300
Cysteine 97 and cysteine 147
Cysteine 325 and cysteine 357
Cysteine 211 and cysteine 261
Cysteine 215 and cysteine 243
Cysteine 268 and cysteine 318
Cysteine 324 and cysteine 375
Cysteine 357 and cysteine 382
Cysteine 154 and cysteine 186
Cysteine 186 and cysteine 211
Cysteine 129 and cysteine 154
Cysteine 318 and cysteine 324
Cysteine 211 and cysteine 243
Cysteine 268 and cysteine 300
Cysteine 243 and cysteine 268
A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 324 and 325.

Details

Redox score ?
73
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
67
Minimum pKa ?
8
% buried
66
Peptide accession
Q3SZN8
Residue number A
324
Residue number B
325
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 324 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 268 and 272.

Details

Redox score ?
72
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
4
Half-sphere exposure sum ?
76
Minimum pKa ?
7
% buried
78
Peptide accession
Q3SZN8
Residue number A
268
Residue number B
272
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 268 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 325 and 375. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
80
Peptide accession
Q3SZN8
Residue number A
325
Residue number B
375
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 325 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 375 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 272 and 308. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
49
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
7
% buried
74
Peptide accession
Q3SZN8
Residue number A
272
Residue number B
308
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 272 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 308 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 90 and 91. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
73
Minimum pKa ?
10
% buried
64
Peptide accession
Q3SZN8
Residue number A
90
Residue number B
91
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 90 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 91 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 300 and 324. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
7
Half-sphere exposure sum ?
68
Minimum pKa ?
13
% buried
80
Peptide accession
Q3SZN8
Residue number A
300
Residue number B
324
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 300 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 324 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 7 and 33. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
62
Minimum pKa ?
12
% buried
82
Peptide accession
Q3SZN8
Residue number A
7
Residue number B
33
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 7 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 33 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 40 and 90. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
71
Minimum pKa ?
12
% buried
78
Peptide accession
Q3SZN8
Residue number A
40
Residue number B
90
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 40 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 90 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 211 and 215. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
66
Minimum pKa ?
10
% buried
50
Peptide accession
Q3SZN8
Residue number A
211
Residue number B
215
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 211 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 215 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 300 and 325. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
8
% buried
77
Peptide accession
Q3SZN8
Residue number A
300
Residue number B
325
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 300 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 325 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 243 and 272. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
43
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
65
Minimum pKa ?
7
% buried
68
Peptide accession
Q3SZN8
Residue number A
243
Residue number B
272
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 243 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 272 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 154 and 204. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
74
Minimum pKa ?
12
% buried
85
Peptide accession
Q3SZN8
Residue number A
154
Residue number B
204
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 154 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 204 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 272 and 300. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
42
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
7
% buried
82
Peptide accession
Q3SZN8
Residue number A
272
Residue number B
300
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 272 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 300 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 97 and 147. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
78
Peptide accession
Q3SZN8
Residue number A
97
Residue number B
147
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 97 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 147 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 325 and 357. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
8
% buried
72
Peptide accession
Q3SZN8
Residue number A
325
Residue number B
357
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 325 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 357 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 211 and 261. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
40
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
8
Half-sphere exposure sum ?
81
Minimum pKa ?
13
% buried
100
Peptide accession
Q3SZN8
Residue number A
211
Residue number B
261
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 211 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 261 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 215 and 243. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
10
% buried
78
Peptide accession
Q3SZN8
Residue number A
215
Residue number B
243
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 215 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 243 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 268 and 318. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
37
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
80
Minimum pKa ?
12
% buried
91
Peptide accession
Q3SZN8
Residue number A
268
Residue number B
318
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 268 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 318 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 324 and 375. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
69
Minimum pKa ?
13
% buried
82
Peptide accession
Q3SZN8
Residue number A
324
Residue number B
375
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 324 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 375 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 357 and 382. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
34
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
68
Minimum pKa ?
12
% buried
80
Peptide accession
Q3SZN8
Residue number A
357
Residue number B
382
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 357 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 382 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 154 and 186. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
67
Minimum pKa ?
12
% buried
80
Peptide accession
Q3SZN8
Residue number A
154
Residue number B
186
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 154 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 186 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 186 and 211. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
69
Minimum pKa ?
12
% buried
80
Peptide accession
Q3SZN8
Residue number A
186
Residue number B
211
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 186 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 211 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 129 and 154. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
32
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
88
Peptide accession
Q3SZN8
Residue number A
129
Residue number B
154
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 129 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 154 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 318 and 324. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
31
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
72
Minimum pKa ?
12
% buried
84
Peptide accession
Q3SZN8
Residue number A
318
Residue number B
324
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 318 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 324 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 211 and 243. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
29
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
9
Half-sphere exposure sum ?
77
Minimum pKa ?
13
% buried
100
Peptide accession
Q3SZN8
Residue number A
211
Residue number B
243
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 211 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 243 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 268 and 300. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
27
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
13
% buried
87
Peptide accession
Q3SZN8
Residue number A
268
Residue number B
300
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 268 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 300 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Ribonuclease inhibitor between cysteines 243 and 268. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
4peq
Structure name
structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease i
Structure deposition date
2014-04-24
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
13
% buried
91
Peptide accession
Q3SZN8
Residue number A
243
Residue number B
268
Peptide name
Ribonuclease inhibitor

Ligandability

Cysteine 243 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 268 of Ribonuclease inhibitor

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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