ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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IGL@ protein

Intramolecular
Cysteine 41 and cysteine 108
Cysteine 157 and cysteine 216
A redox-regulated disulphide may form within IGL@ protein between cysteines 41 and 108 (23 and 90 respectively in this structure).

Details

Redox score ?
79
PDB code
6e9i
Structure name
the crystal structure of bovine ultralong antibody bov-4
Structure deposition date
2018-08-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
94
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3T101
Residue number A
41
Residue number B
108
Peptide name
IGL@ protein

Ligandability

Cysteine 41 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 108 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within IGL@ protein between cysteines 157 and 216 (139 and 198 respectively in this structure).

Details

Redox score ?
78
PDB code
6e9i
Structure name
the crystal structure of bovine ultralong antibody bov-4
Structure deposition date
2018-08-01
Thiol separation (Å)
2
Half-sphere exposure sum ?
88
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3T101
Residue number A
157
Residue number B
216
Peptide name
IGL@ protein

Ligandability

Cysteine 157 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 216 of IGL@ protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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