a tool for identifying drug-targetable redox-active disulphides

GON-4-like protein

Intramolecular

Cysteine 2159 and cysteine 2227 L

A redox-regulated disulphide may form within GON-4-like protein between cysteines 2159 and 2227 (20 and 88 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?

56

PDB code

Structure name

solution structure of mouse hypothetical gene (2610100b20rik) product homologous to myb dna-binding domain

Structure deposition date

2003-06-11

Thiol separation (Å)

8

Half-sphere exposure sum ?

17

Minimum pK_a ?

9

% buried

0

Peptide accession

Residue number A

2159

Residue number B

2227

Peptide name

GON-4-like protein

Ligandability

Cysteine 2159 of GON-4-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 2227 of GON-4-like protein

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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