ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

Intermolecular
Cysteine 70 and cysteine 70
Intramolecular
Cysteine 1057 and cysteine 1094
A redox-regulated disulphide may form between two units of N-acetylglucosamine-1-phosphotransferase subunits alpha/beta at cysteines 70 and 70.

Details

Redox score ?
83
PDB code
7s05
Structure name
cryo-em structure of human glcnac-1-phosphotransferase a2b2 subcomplex
Structure deposition date
2021-08-30
Thiol separation (Å)
2
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide A name
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Peptide B name
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta
Peptide A accession
Q3T906
Peptide B accession
Q3T906
Peptide A residue number
70
Peptide B residue number
70

Ligandability

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within N-acetylglucosamine-1-phosphotransferase subunits alpha/beta between cysteines 1057 and 1094.

Details

Redox score ?
73
PDB code
7s06
Structure name
cryo-em structure of human glcnac-1-phosphotransferase a2b2 subcomplex
Structure deposition date
2021-08-30
Thiol separation (Å)
5
Half-sphere exposure sum ?
54
Minimum pKa ?
9
% buried
16
Peptide accession
Q3T906
Residue number A
1057
Residue number B
1094
Peptide name
N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

Ligandability

Cysteine 1057 of N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 1094 of N-acetylglucosamine-1-phosphotransferase subunits alpha/beta

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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