ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Mesencephalic astrocyte-derived neurotrophic factor

Intramolecular
Cysteine 148 and cysteine 151
Cysteine 27 and cysteine 114
Cysteine 61 and cysteine 72
Cysteine 30 and cysteine 103
Cysteine 27 and cysteine 103
Cysteine 27 and cysteine 30
Cysteine 103 and cysteine 114
Cysteine 30 and cysteine 114
A redox-regulated disulphide may form within Mesencephalic astrocyte-derived neurotrophic factor between cysteines 148 and 151 (140 and 143 respectively in this structure).

Details

Redox score ?
90
PDB code
2rqy
Structure name
solution structure and dynamics of mouse armet
Structure deposition date
2010-01-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
21
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3TMX5
Residue number A
148
Residue number B
151
Peptide name
Mesencephalic astrocyte-derived neurotrophic factor

Ligandability

Cysteine 148 of Mesencephalic astrocyte-derived neurotrophic factor

Cysteine 151 of Mesencephalic astrocyte-derived neurotrophic factor

A redox-regulated disulphide may form within Mesencephalic astrocyte-derived neurotrophic factor between cysteines 27 and 114 (19 and 106 respectively in this structure).

Details

Redox score ?
87
PDB code
2rqy
Structure name
solution structure and dynamics of mouse armet
Structure deposition date
2010-01-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
55
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3TMX5
Residue number A
27
Residue number B
114
Peptide name
Mesencephalic astrocyte-derived neurotrophic factor

Ligandability

Cysteine 27 of Mesencephalic astrocyte-derived neurotrophic factor

Cysteine 114 of Mesencephalic astrocyte-derived neurotrophic factor

A redox-regulated disulphide may form within Mesencephalic astrocyte-derived neurotrophic factor between cysteines 61 and 72 (53 and 64 respectively in this structure).

Details

Redox score ?
86
PDB code
2rqy
Structure name
solution structure and dynamics of mouse armet
Structure deposition date
2010-01-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3TMX5
Residue number A
61
Residue number B
72
Peptide name
Mesencephalic astrocyte-derived neurotrophic factor

Ligandability

Cysteine 61 of Mesencephalic astrocyte-derived neurotrophic factor

Cysteine 72 of Mesencephalic astrocyte-derived neurotrophic factor

A redox-regulated disulphide may form within Mesencephalic astrocyte-derived neurotrophic factor between cysteines 30 and 103 (22 and 95 respectively in this structure).

Details

Redox score ?
83
PDB code
2rqy
Structure name
solution structure and dynamics of mouse armet
Structure deposition date
2010-01-26
Thiol separation (Å)
2
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3TMX5
Residue number A
30
Residue number B
103
Peptide name
Mesencephalic astrocyte-derived neurotrophic factor

Ligandability

Cysteine 30 of Mesencephalic astrocyte-derived neurotrophic factor

Cysteine 103 of Mesencephalic astrocyte-derived neurotrophic factor

A redox-regulated disulphide may form within Mesencephalic astrocyte-derived neurotrophic factor between cysteines 27 and 103 (19 and 95 respectively in this structure).

Details

Redox score ?
72
PDB code
2rqy
Structure name
solution structure and dynamics of mouse armet
Structure deposition date
2010-01-26
Thiol separation (Å)
4
Half-sphere exposure sum ?
59
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3TMX5
Residue number A
27
Residue number B
103
Peptide name
Mesencephalic astrocyte-derived neurotrophic factor

Ligandability

Cysteine 27 of Mesencephalic astrocyte-derived neurotrophic factor

Cysteine 103 of Mesencephalic astrocyte-derived neurotrophic factor

A redox-regulated disulphide may form within Mesencephalic astrocyte-derived neurotrophic factor between cysteines 27 and 30 (19 and 22 respectively in this structure).

Details

Redox score ?
70
PDB code
2rqy
Structure name
solution structure and dynamics of mouse armet
Structure deposition date
2010-01-26
Thiol separation (Å)
5
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3TMX5
Residue number A
27
Residue number B
30
Peptide name
Mesencephalic astrocyte-derived neurotrophic factor

Ligandability

Cysteine 27 of Mesencephalic astrocyte-derived neurotrophic factor

Cysteine 30 of Mesencephalic astrocyte-derived neurotrophic factor

A redox-regulated disulphide may form within Mesencephalic astrocyte-derived neurotrophic factor between cysteines 103 and 114 (95 and 106 respectively in this structure).

Details

Redox score ?
64
PDB code
2rqy
Structure name
solution structure and dynamics of mouse armet
Structure deposition date
2010-01-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
62
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3TMX5
Residue number A
103
Residue number B
114
Peptide name
Mesencephalic astrocyte-derived neurotrophic factor

Ligandability

Cysteine 103 of Mesencephalic astrocyte-derived neurotrophic factor

Cysteine 114 of Mesencephalic astrocyte-derived neurotrophic factor

A redox-regulated disulphide may form within Mesencephalic astrocyte-derived neurotrophic factor between cysteines 30 and 114 (22 and 106 respectively in this structure).

Details

Redox score ?
62
PDB code
2rqy
Structure name
solution structure and dynamics of mouse armet
Structure deposition date
2010-01-26
Thiol separation (Å)
6
Half-sphere exposure sum ?
64
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q3TMX5
Residue number A
30
Residue number B
114
Peptide name
Mesencephalic astrocyte-derived neurotrophic factor

Ligandability

Cysteine 30 of Mesencephalic astrocyte-derived neurotrophic factor

Cysteine 114 of Mesencephalic astrocyte-derived neurotrophic factor

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