phosphatidylinositol-4,5-bisphosphate 3-kinase
Intramolecular
Cysteine 879 and cysteine 883
Cysteine 257 and cysteine 263
Cysteine 883 and cysteine 960
Cysteine 745 and cysteine 749
Cysteine 879 and cysteine 960
Cysteine 263 and cysteine 265
Cysteine 590 and cysteine 627
Cysteine 147 and cysteine 672
2wxf A 879 A 883
A redox-regulated disulphide may form within phosphatidylinositol-4,5-bisphosphate 3-kinase between cysteines 879 and 883.
Details
Redox score ?
66
PDB code
2wxf
Structure name
the crystal structure of the murine class ia pi 3-kinase p110delta in complex with pik-39
Structure deposition date
2009-11-09
Thiol separation (Å)
4
Half-sphere exposure sum ?
86
Minimum pKa ?
9
% buried
100
Peptide accession
Q3UDT3
Residue number A
879
Residue number B
883
Peptide name
phosphatidylinositol-4,5-bisphosphate 3-kinase
Ligandability
Cysteine 879 of phosphatidylinositol-4,5-bisphosphate 3-kinase
Cysteine 883 of phosphatidylinositol-4,5-bisphosphate 3-kinase
2wxh A 257 A 263
A redox-regulated disulphide may form within phosphatidylinositol-4,5-bisphosphate 3-kinase between cysteines 257 and 263.
Details
Redox score ?
61
PDB code
2wxh
Structure name
the crystal structure of the murine class ia pi 3-kinase p110delta in complex with sw14
Structure deposition date
2009-11-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
56
Minimum pKa ?
10
% buried
36
Peptide accession
Q3UDT3
Residue number A
257
Residue number B
263
Peptide name
phosphatidylinositol-4,5-bisphosphate 3-kinase
Ligandability
Cysteine 257 of phosphatidylinositol-4,5-bisphosphate 3-kinase
Cysteine 263 of phosphatidylinositol-4,5-bisphosphate 3-kinase
2wxr A 883 A 960
A redox-regulated disulphide may form within phosphatidylinositol-4,5-bisphosphate 3-kinase between cysteines 883 and 960. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
2wxr
Structure name
the crystal structure of the murine class ia pi 3-kinase p110delta
Structure deposition date
2009-11-09
Thiol separation (Å)
6
Half-sphere exposure sum ?
80
Minimum pKa ?
8
% buried
100
Peptide accession
Q3UDT3
Residue number A
883
Residue number B
960
Peptide name
phosphatidylinositol-4,5-bisphosphate 3-kinase
Ligandability
Cysteine 883 of phosphatidylinositol-4,5-bisphosphate 3-kinase
Cysteine 960 of phosphatidylinositol-4,5-bisphosphate 3-kinase
2wxh A 745 A 749
A redox-regulated disulphide may form within phosphatidylinositol-4,5-bisphosphate 3-kinase between cysteines 745 and 749. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
57
PDB code
2wxh
Structure name
the crystal structure of the murine class ia pi 3-kinase p110delta in complex with sw14
Structure deposition date
2009-11-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
62
Minimum pKa ?
9
% buried
56
Peptide accession
Q3UDT3
Residue number A
745
Residue number B
749
Peptide name
phosphatidylinositol-4,5-bisphosphate 3-kinase
Ligandability
Cysteine 745 of phosphatidylinositol-4,5-bisphosphate 3-kinase
Cysteine 749 of phosphatidylinositol-4,5-bisphosphate 3-kinase
2wxh A 879 A 960
A redox-regulated disulphide may form within phosphatidylinositol-4,5-bisphosphate 3-kinase between cysteines 879 and 960. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
39
PDB code
2wxh
Structure name
the crystal structure of the murine class ia pi 3-kinase p110delta in complex with sw14
Structure deposition date
2009-11-09
Thiol separation (Å)
7
Half-sphere exposure sum ?
81
Minimum pKa ?
14
% buried
100
Peptide accession
Q3UDT3
Residue number A
879
Residue number B
960
Peptide name
phosphatidylinositol-4,5-bisphosphate 3-kinase
Ligandability
Cysteine 879 of phosphatidylinositol-4,5-bisphosphate 3-kinase
Cysteine 960 of phosphatidylinositol-4,5-bisphosphate 3-kinase
5ngb A 263 A 265
A redox-regulated disulphide may form within phosphatidylinositol-4,5-bisphosphate 3-kinase between cysteines 263 and 265. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
37
PDB code
5ngb
Structure name
x-ray diffraction crystal structure of the murine pi3k p110delta in complex with a pan inhibitor
Structure deposition date
2017-03-17
Thiol separation (Å)
10
Half-sphere exposure sum ?
48
Minimum pKa ?
11
% buried
56
Peptide accession
Q3UDT3
Residue number A
263
Residue number B
265
Peptide name
phosphatidylinositol-4,5-bisphosphate 3-kinase
Ligandability
Cysteine 263 of phosphatidylinositol-4,5-bisphosphate 3-kinase
Cysteine 265 of phosphatidylinositol-4,5-bisphosphate 3-kinase
2x38 A 590 A 627
A redox-regulated disulphide may form within phosphatidylinositol-4,5-bisphosphate 3-kinase between cysteines 590 and 627. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
33
PDB code
2x38
Structure name
the crystal structure of the murine class ia pi 3-kinase p110delta in complex with ic87114
Structure deposition date
2010-01-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
63
Minimum pKa ?
12
% buried
92
Peptide accession
Q3UDT3
Residue number A
590
Residue number B
627
Peptide name
phosphatidylinositol-4,5-bisphosphate 3-kinase
Ligandability
Cysteine 590 of phosphatidylinositol-4,5-bisphosphate 3-kinase
Cysteine 627 of phosphatidylinositol-4,5-bisphosphate 3-kinase
2wxq A 147 A 672
A redox-regulated disulphide may form within phosphatidylinositol-4,5-bisphosphate 3-kinase between cysteines 147 and 672. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?
Details
Redox score ?
31
PDB code
2wxq
Structure name
the crystal structure of the murine class ia pi 3-kinase p110delta in complex with as15
Structure deposition date
2009-11-09
Thiol separation (Å)
9
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
94
Peptide accession
Q3UDT3
Residue number A
147
Residue number B
672
Peptide name
phosphatidylinositol-4,5-bisphosphate 3-kinase
Ligandability
Cysteine 147 of phosphatidylinositol-4,5-bisphosphate 3-kinase
Cysteine 672 of phosphatidylinositol-4,5-bisphosphate 3-kinase
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