ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytokine-like nuclear factor N-PAC

Intramolecular
Cysteine 413 and cysteine 416
Cysteine 356 and cysteine 413
A redox-regulated disulphide may form within Cytokine-like nuclear factor N-PAC between cysteines 413 and 416. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
51
PDB code
2uyy
Structure name
structure of the cytokine-like nuclear factor n-pac
Structure deposition date
2007-04-20
Thiol separation (Å)
6
Half-sphere exposure sum ?
86
Minimum pKa ?
12
% buried
96
Peptide accession
Q6P1Q2
Residue number A
413
Residue number B
416
Peptide name
Cytokine-like nuclear factor N-PAC

Ligandability

Cysteine 413 of Cytokine-like nuclear factor N-PAC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 416 of Cytokine-like nuclear factor N-PAC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within Cytokine-like nuclear factor N-PAC between cysteines 356 and 413. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
44
PDB code
2uyy
Structure name
structure of the cytokine-like nuclear factor n-pac
Structure deposition date
2007-04-20
Thiol separation (Å)
8
Half-sphere exposure sum ?
83
Minimum pKa ?
11
% buried
79
Peptide accession
Q6P1Q2
Residue number A
356
Residue number B
413
Peptide name
Cytokine-like nuclear factor N-PAC

Ligandability

Cysteine 356 of Cytokine-like nuclear factor N-PAC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 413 of Cytokine-like nuclear factor N-PAC

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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