ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

Cerebral dopamine neurotrophic factor

Intramolecular
Cysteine 158 and cysteine 161
Cysteine 37 and cysteine 124
Cysteine 71 and cysteine 82
Cysteine 40 and cysteine 113
Cysteine 37 and cysteine 113
Cysteine 40 and cysteine 124
Cysteine 113 and cysteine 124
Cysteine 37 and cysteine 40
Cysteine 40 and cysteine 71
Cysteine 82 and cysteine 113
Cysteine 40 and cysteine 82
A redox-regulated disulphide may form within Cerebral dopamine neurotrophic factor between cysteines 158 and 161 (132 and 135 respectively in this structure).

Details

Redox score ?
91
PDB code
4bit
Structure name
solution structure of cerebral dopamine neurotrophic factor (cdnf)
Structure deposition date
2013-04-13
Thiol separation (Å)
2
Half-sphere exposure sum ?
41
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q49AH0
Residue number A
158
Residue number B
161
Peptide name
Cerebral dopamine neurotrophic factor

Ligandability

Cysteine 158 of Cerebral dopamine neurotrophic factor

Cysteine 161 of Cerebral dopamine neurotrophic factor

A redox-regulated disulphide may form within Cerebral dopamine neurotrophic factor between cysteines 37 and 124 (11 and 98 respectively in this structure).

Details

Redox score ?
87
PDB code
2w50
Structure name
n-terminal domain of human conserved dopamine neurotrophic factor (cdnf)
Structure deposition date
2008-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
61
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q49AH0
Residue number A
37
Residue number B
124
Peptide name
Cerebral dopamine neurotrophic factor

Ligandability

Cysteine 37 of Cerebral dopamine neurotrophic factor

Cysteine 124 of Cerebral dopamine neurotrophic factor

A redox-regulated disulphide may form within Cerebral dopamine neurotrophic factor between cysteines 71 and 82 (45 and 56 respectively in this structure).

Details

Redox score ?
83
PDB code
2w50
Structure name
n-terminal domain of human conserved dopamine neurotrophic factor (cdnf)
Structure deposition date
2008-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
71
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q49AH0
Residue number A
71
Residue number B
82
Peptide name
Cerebral dopamine neurotrophic factor

Ligandability

Cysteine 71 of Cerebral dopamine neurotrophic factor

Cysteine 82 of Cerebral dopamine neurotrophic factor

A redox-regulated disulphide may form within Cerebral dopamine neurotrophic factor between cysteines 40 and 113 (14 and 87 respectively in this structure).

Details

Redox score ?
82
PDB code
2w50
Structure name
n-terminal domain of human conserved dopamine neurotrophic factor (cdnf)
Structure deposition date
2008-12-03
Thiol separation (Å)
2
Half-sphere exposure sum ?
80
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q49AH0
Residue number A
40
Residue number B
113
Peptide name
Cerebral dopamine neurotrophic factor

Ligandability

Cysteine 40 of Cerebral dopamine neurotrophic factor

Cysteine 113 of Cerebral dopamine neurotrophic factor

A redox-regulated disulphide may form within Cerebral dopamine neurotrophic factor between cysteines 37 and 113 (11 and 87 respectively in this structure).

Details

Redox score ?
66
PDB code
2w50
Structure name
n-terminal domain of human conserved dopamine neurotrophic factor (cdnf)
Structure deposition date
2008-12-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
66
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q49AH0
Residue number A
37
Residue number B
113
Peptide name
Cerebral dopamine neurotrophic factor

Ligandability

Cysteine 37 of Cerebral dopamine neurotrophic factor

Cysteine 113 of Cerebral dopamine neurotrophic factor

A redox-regulated disulphide may form within Cerebral dopamine neurotrophic factor between cysteines 40 and 124 (14 and 98 respectively in this structure).

Details

Redox score ?
63
PDB code
2w50
Structure name
n-terminal domain of human conserved dopamine neurotrophic factor (cdnf)
Structure deposition date
2008-12-03
Thiol separation (Å)
5
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q49AH0
Residue number A
40
Residue number B
124
Peptide name
Cerebral dopamine neurotrophic factor

Ligandability

Cysteine 40 of Cerebral dopamine neurotrophic factor

Cysteine 124 of Cerebral dopamine neurotrophic factor

A redox-regulated disulphide may form within Cerebral dopamine neurotrophic factor between cysteines 113 and 124 (87 and 98 respectively in this structure).

Details

Redox score ?
63
PDB code
2w50
Structure name
n-terminal domain of human conserved dopamine neurotrophic factor (cdnf)
Structure deposition date
2008-12-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
73
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q49AH0
Residue number A
113
Residue number B
124
Peptide name
Cerebral dopamine neurotrophic factor

Ligandability

Cysteine 113 of Cerebral dopamine neurotrophic factor

Cysteine 124 of Cerebral dopamine neurotrophic factor

A redox-regulated disulphide may form within Cerebral dopamine neurotrophic factor between cysteines 37 and 40 (11 and 14 respectively in this structure).

Details

Redox score ?
62
PDB code
2w50
Structure name
n-terminal domain of human conserved dopamine neurotrophic factor (cdnf)
Structure deposition date
2008-12-03
Thiol separation (Å)
6
Half-sphere exposure sum ?
68
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q49AH0
Residue number A
37
Residue number B
40
Peptide name
Cerebral dopamine neurotrophic factor

Ligandability

Cysteine 37 of Cerebral dopamine neurotrophic factor

Cysteine 40 of Cerebral dopamine neurotrophic factor

A redox-regulated disulphide may form within Cerebral dopamine neurotrophic factor between cysteines 40 and 71 (14 and 45 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
4bit
Structure name
solution structure of cerebral dopamine neurotrophic factor (cdnf)
Structure deposition date
2013-04-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
70
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q49AH0
Residue number A
40
Residue number B
71
Peptide name
Cerebral dopamine neurotrophic factor

Ligandability

Cysteine 40 of Cerebral dopamine neurotrophic factor

Cysteine 71 of Cerebral dopamine neurotrophic factor

A redox-regulated disulphide may form within Cerebral dopamine neurotrophic factor between cysteines 82 and 113 (56 and 87 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
39
PDB code
4bit
Structure name
solution structure of cerebral dopamine neurotrophic factor (cdnf)
Structure deposition date
2013-04-13
Thiol separation (Å)
10
Half-sphere exposure sum ?
77
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q49AH0
Residue number A
82
Residue number B
113
Peptide name
Cerebral dopamine neurotrophic factor

Ligandability

Cysteine 82 of Cerebral dopamine neurotrophic factor

Cysteine 113 of Cerebral dopamine neurotrophic factor

A redox-regulated disulphide may form within Cerebral dopamine neurotrophic factor between cysteines 40 and 82 (14 and 56 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
36
PDB code
2w50
Structure name
n-terminal domain of human conserved dopamine neurotrophic factor (cdnf)
Structure deposition date
2008-12-03
Thiol separation (Å)
10
Half-sphere exposure sum ?
78
Minimum pKa ?
nan
% buried
nan
Peptide accession
Q49AH0
Residue number A
40
Residue number B
82
Peptide name
Cerebral dopamine neurotrophic factor

Ligandability

Cysteine 40 of Cerebral dopamine neurotrophic factor

Cysteine 82 of Cerebral dopamine neurotrophic factor

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