ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

N-acetyllactosaminide alpha-1,3-galactosyltransferase

Intramolecular
Cysteine 223 and cysteine 298
A redox-regulated disulphide may form within N-acetyllactosaminide alpha-1,3-galactosyltransferase between cysteines 223 and 298 (1223 and 1298 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
25
PDB code
2jcl
Structure name
crystal structure of alpha-1,3 galactosyltransferase (r365k) in the absence of ligands
Structure deposition date
2006-12-26
Thiol separation (Å)
10
Half-sphere exposure sum ?
82
Minimum pKa ?
12
% buried
100
Peptide accession
P14769
Residue number A
223
Residue number B
298
Peptide name
N-acetyllactosaminide alpha-1,3-galactosyltransferase

Ligandability

Cysteine 223 of N-acetyllactosaminide alpha-1,3-galactosyltransferase

Cysteine 298 of N-acetyllactosaminide alpha-1,3-galactosyltransferase

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