ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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protein-serine/threonine phosphatase

Intramolecular
Cysteine 272 and cysteine 294
Cysteine 71 and cysteine 149
A redox-regulated disulphide may form within protein-serine/threonine phosphatase between cysteines 272 and 294. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
38
PDB code
2p8e
Structure name
crystal structure of the serine/threonine phosphatase domain of human ppm1b
Structure deposition date
2007-03-22
Thiol separation (Å)
8
Half-sphere exposure sum ?
76
Minimum pKa ?
11
% buried
92
Peptide accession
Q4J6C0
Residue number A
272
Residue number B
294
Peptide name
protein-serine/threonine phosphatase

Ligandability

Cysteine 272 of protein-serine/threonine phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 294 of protein-serine/threonine phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form within protein-serine/threonine phosphatase between cysteines 71 and 149. However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
33
PDB code
2p8e
Structure name
crystal structure of the serine/threonine phosphatase domain of human ppm1b
Structure deposition date
2007-03-22
Thiol separation (Å)
9
Half-sphere exposure sum ?
83
Minimum pKa ?
12
% buried
100
Peptide accession
Q4J6C0
Residue number A
71
Residue number B
149
Peptide name
protein-serine/threonine phosphatase

Ligandability

Cysteine 71 of protein-serine/threonine phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 149 of protein-serine/threonine phosphatase

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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